PERBEDAAN PARAMETER HEMATOLOGI PADA PASIEN TUBERKULOSIS (TB) DENGAN DAN TANPA INFEKSI HUMAN IMMUNODEFICIENCY VIRUS (HIV)

Aulia Hanif(1*), Safari Wahyu Jatmiko(2), Listiana Masyita Dewi(3), Nining Lestari(4)

(1) Muhammadiyah University of Surakarta
(2) Fakultas Kedokteran, Universitas Muhammadiyah Surakarta
(3) Fakultas Kedokteran, Universitas Muhammadiyah Surakarta
(4) Fakultas Kedokteran, Universitas Muhammadiyah Surakarta
(*) Corresponding Author

Abstract

ABSTRAK

Tuberkulosis (TB) merupakan infeksi oportunistik yang paling sering pada infeksi HIV dan yang paling banyak menyebabkan kematian. Tuberkulosis meningkatkan progresivitas infeksi HIV. Pada pasien TB HIV dan TB non HIV dapat ditemukan berbagai variasi kelainan hematologi seperti leukopenia, trombositopenia dan anemia. Penelitian ini bertujuan untuk mengetahui perbedaan parameter hematologi pada pasien TB HIV dan TB non HIV. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan case control. Subjek penelitian adalah pasien TB HIV dan TB non HIV di Surakarta pada bulan Januari 2017- Oktober 2019. Pengambilan sampel menggunakan teknik consecutive sampling dengan total 60 sampel, terdiri dari 20 pasien TB HIV dan 40 TB non HIV. Pada uji T tidak berpasangan didapatkan perbedaan antara rerata jumlah leukosit, trombosit dan hemoglobin pada pasien TB HIV dan TB non HIV dengan nilai p masing-masing 0,001; 0,005;dan 0,003. Kami menyimpulkan bahwa terdapat perbedaan yang bermakna jumlah leukosit, trombosit dan hemogobin antara pasien TB HIV dan TB non HIV.

Kata Kunci: Tuberkulosis, HIV, Leukosit, Trombosit, Hemoglobin

 

ABSTRACT

Tuberculosis(TB) is the most frequent opportunistic infection in HIV infection and the highest cause of death. Tuberculosis raises progressivity of HIV infection. In TB HIV and TB non HIV patients can be found a wide variety of hematological disorders such as leukopenia, thrombocytopenia and anemia. This study aimed to determine differences in hematological parameters of TB HIV and TB non-HIV. This research is an analytical observational research with a case control approach. The subject of research is TB HIV patient and TB non-HIV at Surakarta in January 2017-October 2019. Sampling uses consecutive sampling techniques with a total of 60 samples, consisting of 20 TB HIV patients and 40 TB non-HIV.The result of independent T test, there is the difference between the number of leukocytes, platelets and hemoglobin in TB HIV and TB non-HIV TB patients with a value of p is 0.001; 0,005; and 0.003. We concluded there were differences in the number of leukocytes, platelets and hemogobin between TB HIV and TB non-HIV. 

Keywords: Tuberculosis, HIV, Leukocytes, Platelets, Hemoglobin

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DOI: 10.23917/biomedika.v12i2.10290

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