EFEK FARMAKOLOGI DAN TOKSIK SIRSAK (Annona muricata): A MINI-REVIEW

Putu Nita Cahyawati

DOI: https://doi.org/10.23917/biomedika.v12i2.10691

Abstract

ABSTRAK

Annona muricata (sirsak) telah digunakan secara tradisional sejak lama untuk mengatasi demam, nyeri, gangguan pernapasan dan kulit, sebagai antiparasit, mengatasi infeksi bakteri, menurunkan tekanan darah, mengatasi peradangan, mengatasi diabetes dan kanker. Oleh karenanya, banyak studi baik in vitro maupun in vivo ditujukan untuk membuktikan manfaat tersebut. Senyawa kimia telah berhasil diisolasi dari tanaman ini diantaranya: alkaloid, fenol, dan asetogenin. Senyawa-senyawa tersebut diyakini berperan terhadap efek farmakologi pada berbagai kondisi penyakit. Walaupun demikian, keamanan atau toksisitas tanaman ini masih dipertanyakan baik untuk pemakaian jangka pendek maupun jangka panjang. Dosis efektif tanaman ini juga belum diketahui secara pasti. Melalui tulisan ini, penulis hendak merangkum berbagai efek farmakologi serta efek toksik yang dapat ditimbulkan oleh Annona muricata berdasarkan hasil penelitian terdahulu.

Kata Kunci: Annona Muricata, Sirsak, Efek Farmakologi, Efek Toksik


ABSTRACT

Annona muricata (sirsak) has been used traditionally for a long time to treated fever, pain, respiratory and skin disorders, as an antiparasitic, to treat bacterial infections, reduce blood pressure, to treat inflammation, diabetes and cancer. Therefore, many studies both in vitro and in vivo were aimed to prove these benefits. Various chemical compounds have been successfully isolated from these plants. These compounds were believed to play a vital role in pharmacological effects in various diseases. Nevertheless, the safety or toxicity of this plant was still questionable for both short and long term use. The effective dose of this plant was also not known with certainty. Through this paper, the author wishes to summarize the various pharmacological and toxic effects that can be caused by Annona muricata based on the results of previous studies.

Keywords: Annona Muricata, Soursop, Pharmacological Effects, Toxic Effects

References

Agu, K.C., Eluehike, N., Ofeimun, R.O., Abile, D., Ideho, G., Ogedengbe, M.O., Onose, P.O., and Elekofehinti, O.O. 2019. Possible anti-diabetic potentials of Annona muricata (soursop): inhibition of α-amylase and α-glucosidase activities. Clinical Phytoscience. 5:21.

Alatas, H., Sja’bani, M., Mustofa, M. Mukti, A.G., Bawazier, L.A., Irijanto, F., Zulaela, Z and Tomino, Y. 2019. The effects of soursop supplementation on blood pressure, serum uric acid, and kidney function in a prehypertensive population in accordance with the 2017 ACC/AHA guideline. J Hum Hypertens. 34:223-232

Arthur, F.K.N., Woode, E., Terlabi, E.O., and Larbie, C. 2011. Evaluation of acute and subchronic toxicity of Annona Muricata (Linn.) aqueous extract in animals. Euro. J. Exp. Bio. 1(4):115-124.

Bento, H.B., Matias, E.F.F., Brito Jr, F.E., Oliveira, D.R., Coutinho, H., Costa, F.G.M., Kerntopf, M.R., and Menezes, I.R.A. 2013. Association Between Food and Drugs: Antimicrobial and Synergistic Activity of Annona muricata L. International Journal of Food Properties. 16(4): 738-744.

Coria-Téllez, A.V., Montalvo-Gónzalez, E., Yahia, E.M., and Obledo-Vázquez, E.N. 2018. Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity. Arabian Journal of Chemistry. 11(5): 662-691.

Dai, Y., Hogan, S., Schmelz, E.M., Ju, Y.H., Canning, C., and Zhou, K. 2011. Selective Growth Inhibition of Human Breast Cancer Cells by Graviola Fruit Extract In Vitro and In Vivo Involving Downregulation of EGFR Expression. Nutrition and Cancer. 63(5):795-801.

Deep, G., Kumar, R., Jain, A.K., Dhar, D., Panigrahi, G.K., Hussain, A., Chapla, A., El-Elimat, T., Ssica, V.P., Oberlies, N.H., and Agarwal, R. 2016. Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cells reducing their proliferation and clonogenicity. Scientific Reports. 6(1):23135.

Djarot, P. 2018. Anti-hyperuricemicactivity of granule formulated from Anonna muricata L. fruit juice on hyperuricemia induce Sprague-Dawleys rat. International Journal of Herbal Medicine. 6(2): 121-126.

Fatimah, S., Arisandi, D., dan Sismawati, S., 2019. Pengaruh pemberian ekstrak etanol buah sirsak (Anonna muricata L.) pada kadar kolesterol low density lipoprotein (LDL) tikus putih (rattus norvegicus) hiperkolesterolemia. Jurnal Biomedika. 12(2): 167-174.

Florence, N.T., Benoit, M.Z., Jonas, K., Alexandra, T., Désiré, D.D., Pierre, K., and Théophile, D. 2014. Antidiabetic and antioxidant effects of Annona muricata (Annonaceae), aqueous extract on streptozotocin-induced diabetic rats. J Ethnopharmacol. 151(2):784-90.

Gavamukulya, Y., Abou-Elella, F., Wamunyokoli, F., and El-Shemy, H. 2014. Phytochemical screening, anti-oxidant activity and in vitro anticancer potential of ethanolic and water leaves extracts of Annona muricata (Graviola). Asian Pac J Trop Med. 7(1):S355-S363.

Gavamukulya, Y., Wamunyokoli, F., and El-Shemy, H.A. 2017. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pacific Journal of Tropical Medicine. 10(9): 835-848.

Gbaguidi, B.A., Anjou, E.S., Koutchiko, A., Dahouenon-Ahoussi, E., Sezan, A., and Dominique, S. 2017. Phytochemical and acute toxicity of ethanolic extract from leaves of Annona muricata (L.) from Benin in experimental albino rats. IJCS. 5(6): 39-4.

Höllerhage, M., Rösler, T.W., Berjas., M., Luo, R., Tran, K., Richards, K.M., Sabaa-Srur, A.U., Maia, J.G.S., de-Moraes, M.R., Godoy, H.T., Höglinger, G.U., and Smith, R.E. 2015. Neurotoxicity of dietary supplements fromAnnonaceaespecies. International Journal of Toxicology. 34(6):543–550.

Ishola, I.O., Awodele, O., Olusayero, A.M., and Ochieng, C.O. 2014. Mechanisms of analgesic and anti-inflammatory properties of Annona muricata Linn. (Annonaceae) fruit extract in rodents. J Med Food. 17(12):1375-82.

Kuswinarti, K., Savira, K., and Rudiman, R. 2018. The Analgesic Effect of Ethanol Extract Soursop (Annona muricata L.) Leaves in Wistar Rats AMJ. 5(4):196–200.

Liaw, C.C., Liou, J.R., Wu, TY, Chang, F.R., and Wu, Y.C. 2016. Acetogenins from Annonaceae. Prog Chem Org Nat Prod. 101:113-230.

Moghadamtousi, S.Z., Fadaeinasab, M., Nikzad, S., Mohan, G., Ali, H.M., and Kadi, H.A. 2015. Annona muricata(Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities. Int. J. Mol. Sci. 16:15625-15658.

Moghadamtousi, S.Z., Kadir, H.A., Paydar, M., Rouhollahi, E., and Karimian, H. 2014. Annona muricataleaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-κB. BMC Complementary and Alternative Medicine. 14(1).

Nwokocha, C.R., Owu, D.U., Gordon, A., Thaxter, K., McCalla, G., Ozolua, R.I., and Young, L. 2012. Possible mechanisms of action of the hypotensive effect of Annona muricata (soursop) in normotensive Sprague-Dawley rats. Pharm Biol. 50(11):1436-41.

Ola-Davies, O.E., Oyagbemi, A.A., Omobowale, T.O., Akande, I., and Ashafa, A. 2019. Ameliorative effects of Annona muricata Linn. (Annonaceae) against potassium dichromate-induced hypertension in vivo: involvement of Kim-1/p38 MAPK/Nrf2 signaling. Journal of Basic and Clinical Physiology and Pharmacology. 30(4): doi:10.1515/jbcpp-2018-0172.

Oridupa, C.O.A., Falade, F.B., Oyagbemi, A.A., Abegunde, B.A., Ekwem, P.C., Badmus A., and Omobowale, T.O. 2018. Annona muricata Linn leaves or Curcuma longa Linn Rhizomes Ameliorates Oxidative Stress Associated with Hypertension in Uninephrectomized Wistar Rats Daily Loaded with Sodium. EJMP. 26(4): 1-13.

Otto, R.B.D., Nankwanga, M., and Sesaazi, D. 2015. Comparison of Antibacterial Activities of Fermented with those of Unfermented Annona muricata (L) Fruit Extracts. Int. J. Curr. Microbiol. App. Sci. 4(6): 696-707.

Oyekachukwu, A.R., Elijah, J.P., Eshu, O.V., and Nwodo, O.F.C. 2016. Anti-Inflammatory Effects of The Chloroform Extract of Annona muricata Leaves on Phospholipase A2 and Prostaglandin Synthase Activities. Transl Biomed. 8(4):137.

Rady, I., Bloch, M.B., Chamcheu, R.N., Mbeumi, S.B., Anwar, M.R., Mohamed, H., Babatunde, A.S., Kuiate, J.R., Noubissi, F.K., El Sayed, K. A., Whitfield, G.K., and Chamcheu, J.C.. 2018. Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review. Oxidative Medicine and Cellular Longevity. 1826170.

Roduan, M.R.M., Hamid, R.A., Cheah, Y.K., and Mohtarrudin, N. 2019. Cytotoxicity, antitumor-promoting and antioxidant activities of Annona muricata in vitro. Journal of Herbal Medicine. 15:100219.

Sasso, S., Sampaio E Souza, P.C., Santana, L.F., Cardoso, C.A.L., Alves, F.M., Portugal, L.C., de Faria, B.B., da Silva, A.F., Motta-Castro, A.R.C., Soares, L.S., Bandeira, L.M., Guimarães R.d.A., and Freitas, K.d.C. 2019. Use of an Extract of Annona muricata Linn to Prevent High-Fat Diet Induced Metabolic Disorders in C57BL/6 Mice. Nutrients. 1(7):1509.

Souza, D.O., Dos Santos Sales V., de Souza Rodrigues C.K., de Oliveira, L.R., Lemos, I.C.S., Delmondes, G.d.A., Monteiro, A.B., do Nascimento, E.P., de Figuêiredo, F.R.S.D.N., da Costa, J.G.M., da Cruz, G.M.P., Viana, G.S.d.B., Barbosa, R., de Menezes, I.R.A., Felipe, C.F.B., and Kerntopf, M.R. 2018. Phytochemical Analysis and Central Effects of Annona Muricata Linnaeus: Possible Involvement of the Gabaergic and Monoaminergic Systems. Iran J Pharm Res.17(4):1306-1317.

Torres, M.P., Rachagani, S., Purohit, V., Pandey, P., Joshi, S., Moore, E.D., Johansson, S.L., Singh, P.K., Ganti, A.K., and Batra, S.K. 2012. Graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism. Cancer Lett. 323(1):29–40.

Vieira, G.H.F., Mourão, J.A., Ângelo, A.M., Costa, R.A., and Vieira, R.H.S.F. 2010. Antibacterial effect (in vitro) of moringa oleifera and annona muricata against gram positive and gram negative bacteria. Rev. Inst. Med. Trop. Sao Paulo. 52(3):129-132.

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