Email this article PENYAKIT FAHR’S DENGAN KEJANG PADA PASIEN KARSINOMA TIROID: SEBUAH LAPORAN KASUS
Iwan Setiawan(1), Sulistyani Sulistyani(2*)(1)
(2) Staf Pengajar Fakultas Kedokteran Universitas Muhammadiyah Surakarta
(*) Corresponding Author
Abstract
ABSTRAK
Penyakit Fahr’s adalah penyakit dengan gangguan neuropsikiatri yang ditandai dengan kalsifikasi di ganglia basalis bilateral dari hasil pemeriksaan pencitraan otak dan biasanya berhubungan dengan gangguan metabolisme fosfor dan kalsium. Artikel ini menyajikan kasus penyakit Fahr’s pada seorang wanita usia 56 tahun dengan karsinoma tiroid dan kejang. Selanjutnya, CT scan kepala menunjukkan adanya kalsifikasi yang simetris bilateral pada ganglia basalis, dan otak kecil. Manifestasi klinis penyakit Fahr’s bervariasi tergantung usia, letak bagian otak yang mengalami kalsifikasi, dalam hal ini gejala yang dominan adalah jenis kejang berulang berupa bangkitan general tonic clonic. Kejang yang terjadi dalam hal ini bisa jadi akibat perubahan hormon tiroid atau akibat kalsifikasi di otak. Belum ada pengobatan khusus pada penyakit ini,.Gejala kejang yang terjadi mendapatkan terapi dengan sodium valproate dan terapi untuk gangguan perubahan hormon tiroidnya.
Kata kunci: Penyakit Fahr’s, Karsinoma Tiroid, Kejang
ABSTRAK
Fahr’s disease is a disease with neuropsychiatric disorder, characterized by bilateral basal ganglia calcification and usually associated with a phosphorus and calcium metabolism disorder. This paper presents a case of Fahr’s disease in a 56-year-old woman with carcinoma thyroid and seizures. Furthermore, CT showed bilateral symmetric basal ganglia and cerebellum calcifications. Clinical manifestations of Fahr’s disease vary depending on age, location of the part of the brain that is calcified, in this case the dominant symptom is recurrent seizures type of the general tonic clonic. Seizures that occur in this case can be resulted of thyroid hormone changes or brain calcification. There is no specific treatment for this disease. The seizures that occur got therapy with sodium valproate and therapy for disorders of thyroid hormone changes.
Key words: Fahr’s Disease, Thyroid Carcinoma, WSeizure
Full Text:
PDF (Bahasa Indonesia)References
Al-Tubaikh, J.A. and Reiser, M.F. 2009. Congenital disease and syndromes. Springer-Verlag Berlin Heidelberg. Pp: 28-9.
Calabrò, R.S., Spadaro, L., Marra, A., and Bramanti, P. 2014. Fahr's disease presenting with dementia at onset: a case report and literature review. Behav Neurol. 750975. Pp: 1-3. doi: 10.1155/2014/750975.
Daroff, R.B., Jancovic, J., Mazziota,.J.C., and Pomeroy, S.C. 2016. Bradley’s Neurology in Clinical Practice. Vol.1, 7th edition. Elsevier. p: 1442.
Farshchian, N., Rostamzedeh, A., Gharib, A., Farzizadeh, Z., and Farzizadeh, M. 2015. Fahr’s Syndrome with Seizure Presentation. J Chem.Pharm.Res. 7(11). Pp: 598-603.
Hozumi, I., Kohmura, A., Kimura, A., Hasegawa, A., Honda, A., Hayashi, Y., Hashimoto, K., Yamada, M., Sakurai, T., Tanaka, Y., Satoh, M., and Inuzuka, T. 2010. High levels of copper, zink, iron, and magnesium, but not calcium in the cerebrospinal fluid of patients with Fahr’s disease. Case Rep Neurol. 2(2). Pp: 46-51 .
Kusumastuti, K., Gunadharma, S., dan Kustiowati, E. 2019. Pedoman Tata Laksana Epilepsi edisi 6. Kelompok studi epilepsy PERDOSSI. Surabaya. Airlangga University Press.
Lungu, M., Romila, A., Nechita, A., Tutunaru, D., and Mariam, C.B. 2019. Neurological Manifestation in thyroid tumors. Acta Med. Mediterr.33. p: 385.
Mufaddel, A.A., and Al-Hassani, G.A. 2014. Familial idiopathic basal ganglia calcification (Fahr’s disease). Neuroscience 2014; vol.19(3) : 171-177.
Ongun, N., Degirmenci, E., and Erdogan, C. 2016. Fahr’s Syndrome Presenting with Epileptic Seizure : Two Case Report. North Clin Istambul. 3(1). Pp: 71-4.
Rangaswamy, Ranjith, V., Vikas, L., and Santosh, R. 2016. Fahr’s disease with seizure presentation. J Assoc Physicians India. Vol 64. Pp: 85-6.
Ropper, A.H., Samuels, M.A., and Klein, J.P. 2014. Adam Victor’s Principles of Neurology. Tenth edition. McGraw Hill. p: 987
Saleem, S., Aslam, H.M., Anwar, M., Anwar, S., Saleem, M., Saleem, A., and Rehmani, M.A.K. 2013. Fahr’s syndrome: Literature review of current evidence. Orphanet J. Rare Dis. 8. P: 156.
Shahidi, G.A., and Safdarian, M. 2017. Fahr’s disease: Idiopethic basal ganglia calcication, Iran J Neurol. 16(1). Pp: 53-4.
Tamijani, S.M.S., Karimi, B., Amini, E., Golpich, M., Dargahi, L., Ali, R.A., Ibrahim, N.M., Mohamed, Z., Ghasemi, R., and Ahmadiani, A. 2015. Thyroid hormones: Posible role in epilepsy pathology. Seizure. 31. Pp: 155-64
Viteva, E., and Djurkova, A. 2015. Fahr’s disease with epilepsy, deafness, schizophrenoform psychosis and autoimmune polymyositis : a case report. An Int. J. Public Health. Rare Disease and Orphan Drugs. 2(2). Pp: 34-7.
Article Metrics
Abstract view(s): 738 time(s)PDF (Bahasa Indonesia): 1610 time(s)
Refbacks
- There are currently no refbacks.
