Email this article EKSPRESI ANTI-HELICOBACTER PYLORI PADA GASTRITIS KRONIS, LESI PRAKANKER, DAN KARSINOMA GASTER
Lina Damayanti(1*), Bambang Hendro Putranto(2), Udadi Sadhana(3)(1)
(2)
(3)
(*) Corresponding Author
Abstract
Prevalence of Helicobacter pylori infection in Indonesia was 36-46%. In Jakarta and Surabaya, the prevalence were 85,7%-93,9%. Helicobacter pylori infection play role in pathogenesis of pectic ulcers, chronic gastritis, carcinoma of gaster and gastric lymphoma. Epidemiologic study showed 80% of carcinoma of gaster related with H pylori infection.This study analyzed expression of anti-Helicobacter pylori in chronic gastritis, precancer lesion , and carcinoma of gaster. This study was a observational descriptive study with case control design. Thirty (30) samples from paraffin bloc that were diagnosed with chronic gastritis, precancer lesion, and carcinoma of gaster at Dokter Kariadi hospital in 2013 was stained by hematoxylin eosin, giemsa and immunohistochemistry of anti-helicobacter pylori. Data was analyzed by descriptive analysis. Thirty (30) samples were diagnosed as gastritis chronis 13 (43,3% ), pra cancer lesion(36.6%), and carcinoma(20.1%). Chronic gastritis can be occurred at all age and no distinct difference on sex, while gastric carcinoma predominant in male older than 40 years. Expresion of Helicobacter pylori on chronic gastritis was 84.6%, precancer lesion was 54.5%, and gastric carcinoma was 83.3%. The Giemsa stain gave 23.3% false positive and 20% false negative. Helicobacter pylori expression can be showed in chronic gastritis, precancer lesion, and gastric carcinoma.
Keywords: Chronic gastritis, gastric carcinoma, Helicobacter pylori
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Ahmed N, Tenguria S, Nandawar N., 2014.Helicobacter pylori- a seasoned pathogen by any other name. Gutpathogen. Available from http://
www.gutpathogens.com/content/1/1/24
Charalabopoulos K, Papalimneou V, Agnantis NJ.2003., Pathogenetic mechanism involved in stomach infection caused by Helicobacter pylori.Hipokratia, 7(4):173-76
Dixon M.F., 2001. Pathology of gastritis and peptic ulceration in Mobley HLT, Mendz GL, Hazell SL,(eds).Helicobacter pylori:Pysiology and
genetics.Washington:ASM Press
Eugenia SD. 2011.,Histopathological study and immunohisthochemical studi of gastric carcinoma. Doctoral thesisSummary.
E, Oktaviyanti I.K, Rosida L., 2013.Gambaran derajat infiltrasi sel radang dan infeksi Helicobacter pylori pada biopsi lambung pasien gastritis.Berkala Kedokteran. 9(1):47-551.
Komoto K, Haruma K, Kamada T, Tanaka S, Yoshihara M, Sumii K, et al., 1998. Helicobacter pylori Infection and gastric neoplasia: Correlation with histological gastritis and tumor histology. Am J Gastroenterol. 93(8):1271-7.
Maeda S, Yoshida H, Ogura K, Yamaji Y, Ikenoue T, Mitsushima T, et al., 2000. Assessment of gastric carcinoma risk associated with Helicobacter pylori may vary depending on the antigen used. CagA specific Enzyme- Linked Immunoadsorbent Assay (ELISA) versus commercially available H.pylori ELISAs. Cancer.88 (7):1530-5.
Micu G, staniceanu F, Zurac S, Bastian A, Gramada E, Nichita L,et al., 2010.Carcinogenesis and infection with Helicobacter pylori.Rom J Intern.48(4):299-306
Miehlke S, Hackelsberger A, Meining A, Arnim IV, Muller P, et al.. 1997. Histological diagnosis of Helicobacter pylori gastritis is predictive of a high risk gastric cancer carcinoma. Int J.Cancer. 73:837-9.
Nagini S.,2012. Carcinoma of the stomach: a review of epidemiology, pathogenesis, molecular genetics and chemoprevention. World J Gastrointest Oncol. 15: 4(7): 156-69 Noda N, Wakasugi H. 2004. Cancer and Oxidative stress.J JMA, 124(11):1571-74
Parsonett J, Friedman G.D, Daniel M.S, Vandersteen D.P, Chang Y, Vogelman J.H et.al., 1991. Helicobacter pylori infection and the risk of gastric carcinoma.NEng JMed, 325:1127-31
Paz-Bouzal J.I. Garcia, Abad M.M, Muaozl E, Rincon M.R, Bullon A., 1991. Chronic gastritis associated with helicobacter pylori. Correlation between histological and bacteriogical.Histol Histopath.6:485-9
Semino-Mora C, Doi SQ, Marty A, Simko V, Caristedt I, Dubois A., 2003.Intracellular and interstitial expression of Helicobacter pylori virulence genes in gastric precancerous intestinal metaplasia and adenocarcinoma.J Inf Dis.187 : 1165-77.
Suzuki H, Nishizawa T, Masaoka T, Mori M, Iwasaki E, Tsicimoto K,et al., 2005. Helicobacter pylori and gastric cancer. JMAJ, 48(10):497-04
Syaifudin M. 2008. Pengembangan teknik biologi molekuler untuk deteksi Helicobacter pylori pada penderita dyspepsia.available from http://www.nhc.batan.go.id/syaifudin.php1
Tokudome S, Samsuria W.D, Soeripto, Triningsih F.X.E, Suzuki S, Hosono A,et al., 2005. Helicobacter pylori infection appears essential for stomach carcinogenesis : observations in Semarang, Indonesia.Cancer Sci, 96(12):873-75.
Valko M, Izakovic M, Mazur M, Rhodes CJ, Telser J., 2004. Role of oxygen radicals in DNA damage and cancer incidence.Mol cell Biochem,266:37-56
Yuan JP, Li T, Chen HB, Li ZH, Yang GZ,Hu BY, et al., 2004. Analysis of gene expression profile in gastric cancer cells stimulated with Helicobacter pylori isogenic strains. J Med Microbiol, 53:965-74
Zhang C, Yamada N, Wu YL, Wen M, Matsuhisa T, Matsukura N., 2005. Helicobacter pylori infection, glandular atrophy and intestinal metaplasia in superficial gastritis, gastric erosion, erosive gastritis, gastric ulcer, and early gastric cancer. World J Gastroenterol,11(6): 791-6.
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