EFEK ANTIINFLAMASI INFUSA RIMPANG TEMU PUTIH (Curcuma zedoaria (Berg) Roscoe) PADA TIKUS YANG DIINDUKSI KARAGENIN

Tanti Azizah Sujono, Raudatul Patimah, Ratna Yuliani

DOI: https://doi.org/10.23917/biomedika.v4i2.253

Abstract

In-flammation is the bodys reaction to foreign substances that enter the body with signs of redness, heat, swelling, pain, and impaired organ functions. Curcuma rhizome including medicinal plants that have properties relieve the pain and inflammation of the skin. The purpose of this research was to examine the anti-iflammation effect of Curcuma zedoaria (Berg) Roscoe Rhizome infusion on carrageenan induced paw edema in rats. This research used experimental method with completely randomized design. Twenty five healthy Wistar male rats, 2-3 months old and 150-250 g divided into five groups and each group consist of 5 rats. Rats in group I that served as negative control were given 2.5 mL/200gbw of aquadest. Rats in group II as positive control were given sodium diclofenac with dose of 6.75 mg/kgbw. Group III, IV, and V were given Curcuma zedoaria (Berg) Roscoe Rhizome infusion with dose of 0.625, 1.250 and 2.500 g/kgbw, respectively. Treatments were given per oral 1 hour before injection of 0.1 ml carrageenan 1% subplantar. Rat paw edema volume was measured before and after carrageenan injection. The measurement was done every 0.5 hour for 6 hours observation. Area Under the Curve (AUC) that is calculated from paw edema volume data, was use to calculate percentage of anti-inflammatory effect. Data were analyzed with one way Anova and Least Signifi cant Difference with confi dence level 95%. Infusion of Curcuma zedoaria Rhizome with doses of 0,625, 1,250, and 2,500 g/kgbw had anti-inflammatory effect in Wistar male rats which were induced by Carrageenan 1%. Percentage of anti-inflammation effect (44,16+5,11)%, (48,70+7,05)%, (59,09+9,61)% respectively and the effects were equivalent with positive control.

Key words: Anti-inflammation, Curcuma zedoaria (Berg) Roscoe, infusion, Carrageenan.

Full Text:

PDF

References

Anonim, 1995, Farmakope Indonesia, Edisi Keempat, IV, Departemen Kesehatan Republik Indonesia, Jakarta.

Anonim, 2000, Acuan Sediaan Herbal, Edisi I, Departemen Kesehatan RI, Dirjen Pengawasan Obat dan Makanan, Jakarta.

Anonim, 2009, Penelitian Efek Antiin� amasi Beberapa Tanaman Obat pada Tikus Putih, Pusat Penelitian Dan Pengembangan Farmasi, Badan Penelitian dan Pengembangan Kesehatan Departemen Kesehatan R.I., Jakarta.

Corsini, E., Paola R.D., Viviani, B., Genovese, T., Mazzon, E., Lucchi, L., et al., 2005, Increased Carrageenan-Induced Acute LungIn ammation in Old Rats, Immunology, 115 (2):253-61.

Dalimartha, S., 2005, Atlas Tanaman Obat Indonesia, Jilid 3, Cetakan ke-4, 170-171, Puspa Swara, Jakarta.

Robbins, S., Kumar, V., dan Cotran R. S., 2007, Buku Ajar Patologi, Diterjemahkan oleh Pendit, B., Edisi 7, Buku Kedokteran EGC, 625-627, Jakarta.

Santoso, H. B., 1998, Tanaman Obat Keluarga III, Kanisius, Jakarta.

Siswanto, A., dan Nurulita, N.A., 2005, Daya Antiin� amasi Infus Daun Mahkota dewa (Phaleria macrocarpa Scheff Boerl) pada Tikus Putih (Rattus norvegicus) Jantan, Prosiding Seminar Nasional TOI XXVII.

Sudjarwo, S. A., 2003, Potensi Kurkumin Sebagai Antiin� amasi pada Mencit yang Diinduksi dengan Karagen, Med. Ked. Vet., Jakarta.

Vogel, H.G., 2008, Drug Discovery and Evaluation :Pharmacolog

Article Metrics

Abstract view(s): 358 time(s)
PDF: 1322 time(s)

Refbacks

  • There are currently no refbacks.