Ratih Pramuningtyas



Over the last decade, there has been a rise in the number of surgical procedures being perfomed under local anethesia. The infiltration of the local anesthetic is the most painful part of this procedures, and pain associations can develop into avoidance behaviors in future procedures. Several techniques were used to reduce the pain of local anesthetic infiltration. The objective of this study is comparing the effect of Buffered Pehacaine versus freshly mixed lidocaine-epinephrin in reducing the pain of local anesthetic infiltration. Six subject were recruited for this study. Each subject was received 2 kind of treatment. Subject rated pain using Visual Analog Score. Pain score were compared using paired t test. Sixty seven percent (67%) subjects reported that pain of infiltration was lower in Buffered pehacaine than freshly mixed lidocaine-epinephrine. The difference was not statistically significant. There are no significant difference between Buffered Pehacaine versus freshly mixed lidocaine-epinephrin in reducing the pain of local anesthetic infiltration

Keywords : local anesthetic infiltration, lidocaine, pehacaine

Full Text:



Leff DR, Nortley M, Dang V, Bhutiani RP,.The effect of local cooling on pain perception during infi ltration of local anaesthetic agents, a prospective randomised controlled trial.

Anaesthesia. 2007; 62: 677-82 Shahwan MA,.Prospective comparison between buffered 1% lidocaine epinephrine and skin cooling in reducing the pain of local anesthetic infiltration. Dermatologic

Surgery. 2012; 38:16549 Burns CA, Ferris G, Feng C, Cooper JZ, Brown MD,. Decreasing the pain of local anesthesia: A prospective, double-blind comparison of buffered, premixed 1% lidocaine with epinephrine versus 1% lidocaine freshly mixed with epinephrine. Journal of The American Academy of Dermatology. 2005; 54: 128-31

Willey A, Lee PK,. Cutaneous anesthesia. in : Roenigk RK, Ratz JL, Roenigk HH. Roenigks Dermatologic Surgery Current Techniques in Procedural Dermatology. 3rd ed. New York. Informa Healthcare. 2007: 55-9

Bart� eld JM, Kathleen M, Crisafulli, Robak RR,

Salluzzo RF,. The effects of warming and

buffering on pain of in� ltration of lidocaine.

Academic Emergency Medicine. 1995; 2:


Henning JS, Firoz BF,. The use of cooling device as an

analgesic before injectable local anesthesia

in the pediatric population. Dermatologic

surgery. 2010; 36: 520-3

Gursoy A, Ertugrul DT, Sahin M, Tutuncu NB, Demirer AN, Demirag NG,. The analgesic efficacy of lidocaine/prilocaine (EMLA) cream during � ne-needle aspiration biopsy of thyroid nodules. Turkish Journal of Endocrinology and Metabolism. 2007; 66: 691-4

Hruza GJ. Anesthesia. In : Bolognia JL, Jorizzo JL, Rapini RP,. Dermatology. 2nd edition. New York. Mosby Elsiever. 2008 : 2173-81

Xia Y, Chen E, Tibbits DL, Reilley TE, McSweeney TD. Comparison of effects of lidocaine hydrochloride, buffered lidocaine, diphenhydramine, and normal saline after intradermal injection. Journal of Clinical Anesthesia. 2001; 14: 33943

Fatovich DM, Jacobs IG,. A randomized controlled trial of buffered lidocaine for local anesthetic infiltration in children and adults with simple lacerations. The Journal of Emergency Medicine. 1999; 17: 2238

Article Metrics

Abstract view(s): 474 time(s)
PDF: 3628 time(s)


  • There are currently no refbacks.