Safari Wahyu Jatmiko



Basophils are polymorphonuclear leukocytes that play an important role in immunity. Basophils can be activated by antibodies and other molecules. Basophils are able to recognize antigens of worms and give some responses. Basophils involvement in immunity againt worms are played by migratingto the worm infected tissue, trigger eosinophilia and eosinophil migration into the tissue, activating mast cells, triggering the formation of AAM, directing Th cell polarization toward Th2 cells, and triggers immunoglobulin class switching to produce IgE.

Keywords:Basophil, Helminthiasis

Full Text:



Ahrens R, Waddell A, Seidu L, Blanchard C, Carey R, Forbes E, Lampinen , Wilson T, Cohen E, Stringer K, Ballard E, Munitz A, Xu H, Lee N, Lee JJ, Rothenberg ME, Denson L, Hogan SP, 2008, Intestinal Macrophage/Epithelial Cell-Derived CCL11/Eotaxin-1 Mediates Eosinophil Recruitment and Function in Pediatric Ulcerative Colitis,J Immunol; 181, 73909.

Arock, M., Schneider, E., Boissan, M., Tricottet, V., Dy, M., 2002, Differentiation of human basophils: an overview of recent advances and pending questions, J. Leukoc. Biol. 71,


Aumüller E, Schramm G, Gronow A, Brehm K, Gibbs BF, Doenhoff MJ, Haas H, 2004, Echinococcus multilocularis metacestode extract triggers human basophils to release interleukin-4, Parasite Immunol;26, pg 387-95.

Bashir MEH, Andersen P, Fuss IJ, Shi HN, Nagler-Anderson C, 2002, An Enteric Helminth Infection Protects Against an Allergic Response to Dietary Antigen,J Immunol

: 3284-92.

Brattig, NW., Bazzocchi, C., Kirschning, CJ., Reiling, N., Büttner, DW., Ceciliani., F., et al, 2004, The Major Surface Protein of Wolbachia Endosymbionts in Filarial Nematodes

Elicits Immune Responses through TLR2 and TLR4, J Immunol,173,437-45

Byers DE, Holtzman MJ, 2010, Alternatively Activated Macrophages as Cause or Effect in Airway Disease, Am J Respir Cell Mol Biol; 43. pg 1-4,

Cadman, E. T., Lawrence, R. A., Granulocytes: effector cells or immunomodulators in the immune response to helminth infection?, Parasite Immunol, 32, 1-19

Ciesla, B., 2007, Hematology in Practice, 1 st ed, Philadelphia: FA Davis, pg 129-39

Article Metrics

Abstract view(s): 373 time(s)
PDF: 2388 time(s)


  • There are currently no refbacks.