PEMISAHAN SENYAWA-SENYAWA YANG BERSIFAT SITOTOKSIK TERHADAP SEL MURIN LEUKEMIA P388 DARI EKSTRAK METANOL KULIT BATANG DIPTEROCARPUS CONFERTUS SLOOT (DIPTEROCARPACEAE)

. Muhtadi(1*), Peni Indrayudha(2)

(1) 
(2) 
(*) Corresponding Author

Abstract

Six compounds, KP-1 up to KP-6 were isolated from the methanol extract of the tree bark of Dipterocarpus confertus Sloot (Dipterocarpaceae). The cytotoxic activities of these compounds were evaluated against murine leukemia P388 cells. Result of these examination indicated that KP-2 compound and KP-1 were very active with each IC 50 value of these compounds were 2.25 and 5.1 μg/mL, respectively. While the others were not active against murine leukemia P388 cells.

Keywords: Dipterocarpaceae, Dipterocarpus confertus Sloot, isolated compounds, cytotoxic, and leukemia P-388 cell

Full Text:

PDF

References

Alley, M.C., Scudiero, D.A., Monks, A., Hursey, M.L., Czerwinski, M.J., Fine, D.L., Abbott, B.J., Mayo, J.G., Shoemaker, R.H., Boyd, M.R. (1988) : Feasibility of Drug Screening with Panels of Human Tumor Cells Lines Using a Microculture Tetrazolilum Assay, Cancer Res., 48, 589-601.

Bokel, M., M.N.C. Diyasena, A.A.L. Gunatilaka, W. Kraus, S. Sotheeswaran (1988), Caliculatol, an antifungal resveratrol trimer from Stemonoporus canaliculatus, Phytochemistry, 27, 377-380

Cronquist, A. (1981), An intergrated system of classifi cation of fl owering plant, Columbia University Press, New York, 317-318 Dai, J.R., Y.F. Hallock, J.H. Cardellina II,

M.R., Boyd (1998), HIV-Inhibitory and cytotoxic oligostilbenes from the leaves of Hopea malibato, J. Nat. Prod., 61, 351-353

Geewananda, Y.A., P. Gunawardena, S. Sotheeswaran, M.U.S. Sultanbawa, S. Surendrakumar,

P. Bladon (1986), Another antibacterial polyphenol, coppaliferol B, from Vaterian copallifera (Dipterocarpaceae), Phytochemistry, 25, 1498-1500

Hakim, E.H. (2002), Oligostilbenoid dari tumbuh- tumbuhan Dipterocarpaceae, Bull. Soc. Nat. Prod. Chem., 2, 1-9

Hegnauer, R. (1966), Chemotaxonomie der pfl anzen, Band 4, Birkhauser Verlag Basel und Stuttgart, 31-40

Heyne, K. (1987), Tumbuhan berguna Indonesia, Vol II, Balai Kehutanan Indonesia, Departemen Kehutanan, Jakarta, 1420 Hirano, Y., R.

Kondo, K. Sakai (2001), Compounds inhibitory to rat liver 5fi-reductase from tropical commercial wood species: resveratrol trimers from melapi (Shorea sp.) heartwood, J. Wood. Sci., 47, 308-312

DOI: 10.23917/biomedika.v5i1.269

Article Metrics

Abstract view(s): 386 time(s)
PDF: 967 time(s)

Refbacks

  • There are currently no refbacks.