EFEK GEL EKSTRAK HERBA PEGAGAN (Centella asiatica L. Urban) DENGAN GELLING AGENT HIDROKSIPROPIL METHYLCELLULOSE TERHADAP PENYEMBUHAN LUKA BAKAR PADA KULIT PUNGGUNG KELINCI
Tanti Azizah Sujono(1*), Ullya Nur Wahyu Hidayah(2), T.N. Saifullah Sulaiman(3)(1) 
(2) 
(3) 
(*) Corresponding Author
Abstract
Pegagan (Centella asiatica L. Urban) contain saponin asiaticoside, which is a structural protein. The compound plays a role in the wound healing process by the formation of collagen. This research was conducted to determine the effect of wound healing of burns on New Zealand male rabbits using gel extract of Pegagan (Centella asiatica L. Urban) herbs using hydroxypropyl methylcellulose (HPMC) as gelling agent. This research was an experimental with the same subject design, using � ve male New Zealand rabbits to test the wound healing of burns, and the backs of each rabbit were divided into six treatment i.e : positive control (Bioplasenton), negative control (no treatment), control HPMC base (no extract), and three formula with herbal extracts of Centella asiatica with a concentration of gelling agent HPMC 8%, 9%, and 10% respectively. Gel was applied to the back of rabbits with the use ± 0.3 grams once daily until the wound diameter equal to zero or until healed. The data was analyzed by one way anava with a 95% confidence level. The result showed that of the gelling agent HPMC concentration effect on the increased the viscosity, and decreased the spreadability and the burn wound healing time is a longer. Gel herb pegagan extract (Centella asiatica L. Urban) with a gelling agent HPMC concentration of 8% (17,60±1,14 days) most effectively heal burns compared to the concentration of 9% (19,40 ±1,14 days) and concentration 10% (20,40±1,14 days).
Keywords: Centella asiatica L. Urban, gel, hydroxypropyl methylcellulose, burns.
Full Text:
PDFReferences
DepKes RI, 2008, Farmakope Herbal Indonesia, 113-115, Departemen Kesehatan Republik Indonesia, Jakarta.
Erwati, Tristiana, Rosita, N. , Hendroprasetyo, W. & Dien R. J., 2005, Pengaruh Jenis Basis Gel Dan Penambahan NaCl (0.5% -b/b) Terhadap Intensitas Echo Gelombang
Ultrasonik Sediaan Gel Untuk Pemeriksaan USG (Acoustic Coupling Agent), Airlangga
Journal of Pharmacy, 5 (2). Gibson, M., 2001, Pharmaceutical Preformulation and
Formulation, 546-550, CRC Press, United States of America.
Grace, A. P. & Borley, N. R., 2007, Ilmu Bedah Edisi III, 87, Penerbit Erlangga, Jakarta.
Kibbe, A.H., 2004, Handbook of Pharmaceutical Exipients, Third Edition, 18-19, 462-469,
-631, Pharmaceutical Press. London.
Kim, W.J., Kim, J., Veriansyah, B., Kim, J.D., Lee, S.G., & Winata, R.R.T., 2009, Extraction of Bioactive Components from Centella asiatica Using Subcritical Water, The
Journal of Supercritical Fluid, 48, 211-216
Lee, T.K., & Vairappan, C.S., 2011, Antioxidant, Antibacterial and Cytotoxic Activities
of Essential Oils and Ethanol Extracts of Selected South East Asian Herbs, J Med
Plant Res, 5 (21), 5284-5290 MacKay D. & Miller A. L., 2003, Nutritional Support
for Wound Healing, Alternative Medicine Review, 8, 369-370.
....
Madan, J. & Singh, R., 2010, Formulation and
Evaluation of Aloe vera Gels, Int J Ph Sci,
(2) : 551-555
Martin, A., Swarbrick, J. & Cammarata, A., 2008,
Farmasi Fisik, Edisi Ketiga, Penerbit UI
Press, Jakarta.
Rismana, E., 2010, Pengembangan Formulasi Sediaan
Wound Healing Menggunakan Bahan Aktif
Kitosan dan Ekstrak Pegagan, BPPT, Jakarta
Rogers, T.L., 2009, Hypromellose, Rowe, R. C., Paul J.
S., & Marian E. Q., Sixth Edition, 326-329,
Handbook of Pharmaceutical Excipient,
Pharmaceutical Press, USA.
Sikarrepaisan, P., Suksamrarn, A., & Supaphol, P., 2008,
Electrospun Gelatin Fiber Mats Containing
A Herbal Centella asiatica Extract and
Release Characteristic of Asiaticoside,
Nanotechnology, 2.
Suardi, M., Armenia & Maryawati, A., 2008, Formulasi
dan Uji Klinik Gel Anti Jerawat Benzoil
Peroksida-HPMC, Karya Ilmiah, Fakultas
Farmasi Universitas Andalas, Sumatra Barat.
Sudarsono, Gunawan, D., Wahyuono, S., Donatus,
I.A., & Purnomo, 2002, Tumbuhan Obat II,
-45, Pusat Studi Obat Tradisional UGM,
Yogyakarta
Article Metrics
Abstract view(s): 2895 time(s)PDF: 2763 time(s)
Refbacks
- There are currently no refbacks.