FARMAKOGENETIK PENGOBATAN BETA 2 AGONIST DAN STEROID PADA PENDERITA ASMA

EM Sutrisna

DOI: https://doi.org/10.23917/biomedika.v6i2.277

Abstract

In the worldwide about 300 million people have asthma. β-2 agonists and steroids are widely prescribed drugs in the treatment of asthma. Different responses raises the suspicion of a genetic infiuence on the hosts response to the treatment of this disease. The purpose of this review is to provide a comprehensive understanding of the infiuence of genetic factors on the treatment of asthma. This review is done by the method in Pubmed search using keywords Pharmacogenetic asthma; polymorphism beta agonist AND asthma. The analysis shows that there are several genes that affect treatment response. ADRB2 gene affects the bronchodilatation response for asthmatics treated with β-2 agonist. CRHR1 gene polymorphism, Glucocorticoid-complex genes, and CER2 genes and TBX21 genes affect the response to corticosteroids inhalers.


Keywords: Asthma, Pharmacogenetics, Treatment response

Full Text:

PDF

References

Antisira KG, Hwang ES, Raby BA, Silverman ES, Lake SL, Richter BG, et al. TBX21: afunctional variant predicts improvement in asthma with the use of inhaled corticosteroids. Proc Natl Acad Sci U S A. 2004; 101(52):18099-18104

Blake KV, Feng H, Tantisira K, et al. Bronochodilator response and B2-adrenergic receptor ADRB2 haplotype tagging single nucleotide polymorphisms (htSNPs) [abstract]. Am J Respir Crit Care Med 2008;177:A568.

Bleecker ER, Nelson HS, Kraft M, Corren J, Meyers DA, Yancey SW, et al. Beta2-receptor polymorphisms in patients receiving salmeterol with or without fiuticasone propionate. Am J Respir Crit Care Med. 2010; 181(7):676-687. [PubMed: 19910613]

Bleecker ER, Postma DS, Lawrance RM, Meyers DA, Ambrose HJ, Goldman M. Effect ofA DRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies. Lancet. 2007; 370(9605):21182125. [PubMed:18156033]

Choudhry S, Ung N, Avila PC, et al. Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med 2005;171:563-570. [PubMed:15557128]

Finotto S, Neurath MF, Glickman JN, Qin S, Lehr HA, Green FH, et al. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science. 2002;295(5553):336-338.

Fischer A, Konig W. Regulation of CD23 expression, soluble CD23 release and immunoglobulin synthesis of peripheral blood lymphocytes by glucocorticoids. Immunology. 1990; 71(4):473-479.

Green SA, Turki J, Bejarano P, et al. Infiuence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am J Respir Cell Mol Biol 1995;13:25-33.[PubMed: 7598936]

Green SA, Turki J, Innis M, Liggett SB. Amino- terminal polymorphisms of the human beta 2- adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry 1994;33:9414-9419. [PubMed: 7915137](Erratum in Biochemistry 1994 29; 33:14368)

Hawkins GA, Lazarus R, Smith RS, Tantisira KG, Meyers DA, Peters SP, et al. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. J Allergy Clin Immunol. 2009; 123(6):1376-1383.e1377

Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, et al. The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. Am J Respir Crit Care Med. 2000; 162(1):75-80. [PubMed: 10903223]

Johnson M. Molecular mechanisms of beta(2)- adrenergic receptor function, response, and regulation. J Allergy Clin Immunol. 2006; 117(1):18-24. quiz 25. [PubMed: 16387578]

...

Article Metrics

Abstract view(s): 168 time(s)
PDF: 1796 time(s)

Refbacks

  • There are currently no refbacks.