Korelasi Jumlah Netrofil, Limfosit, dan Monosit dengan Kadar Albumin Urin pada Pasien DM Tipe 2 dengan Mikroalbuminuria

Edy Purwanto

DOI: https://doi.org/10.23917/biomedika.v1i1.287


The most common complication of diabetes is diabetic nephropathy which is a progressive disease and in the terminal stages, needs a very large cost of care. Nephropathy diabetic can be prevented if it is detected earlier. Microalbuminuria is a test to detect nepropathy diabetic early nowadays, but it is still considered expensive by the majority of the community and has not been widely done in laboratories. What ever it needs other alternatives, such as neutrophils, lymphocyte, and monocyte counts. The purpose of this study is to analyse the correlations between neutrophils, lymphocyte, monocyte counts and urine albumin levels in type2 diabetes with microalbuminuria. The research design is analytic observational with cross sectional approach. Twenty two patients met the inclusion criteria. Their urine albumin levels tested by Nycocard® U-ALBUMIN reagent. Neutrophils, lymphocyte, monocyte count was examined by hematology analyzer CELL-Dyn 3700. The correlations between neutrophils, lymphocyte, monocyte counts and urine albumin levels analyzed using coefficient correlation Spearman's. No correlation between neutrophil countsand urine albumin levels (r= -0,250;p=0,263). No correlation between monocyte counts and urine albumin levels (r= -0,191;p=0,395). No correlation between lymphocyte counts and urine albumin levels (r=0,130;p=0,565) in type 2 diabetes with microalbuminuria. No correlation between neutrophils, lymphocyte, monocyte counts and urine albumin level in type 2 diabetes patients with microalbuminuria

Keywords: type 2 diabetes, neutrophils, lymphocytes, monocytes, microalbuminuria.

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Anonymous. CellDyn 3700 Instruction Manual

Anonymous. 2002. NycoCard R U-ALBUMIN Pocket insert. Osslo: AXIS-SHIELD

Bennet, B.D., et al. 1996. A role for leptin and its cognate receptor in hematopoiesis. Curr Biol 6: 1170-80

Brown, D.W., Giles, W.H., Croft, J.B. 2001. White blood cell count: an independent predictor of coronary heart disease mortality among a national cohort. J Clin Epidemiol 54: 31622

Chan, C. Juliana. 2004. White blood cell count is associated with macro- and microvascular complications in Chinese patients with type 2 diabetes. Diabetes Care 27: 216-22

Chung, F.M., et al. 2005. Peripheral Total and Differential Leukocyte Count in Diabetic Nephropathy. Diabetes Care 28: 1710-7

Danesh, J., et al. 1998. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA 279: 1477-82

Festa, A., D'Agostino, R., Howard, G., Mykkanen, L., Tracy, R . P. , H a f f n e r, S . M . 2 0 0 0 . I n f l a m m a t i o n a n d microalbuminuria in nondiabetic and type 2 diabetic

subjects: the Insulin Resistance Atherosclerosis Study. Kidney Int 58: 170310

Fuster, V., Lewis, A. 1994. Mechanisms leading to myocardial infarction: insights from studies of vascular biology. Circulation 90: 212646

Gabazza, E.C., Takeya, H., Deguchi, H., Sumida, Y., Taguchi, O., Murata, K. et al. 1996. Protein C activation in NIDDM patients. Diabetologia 39: 145561

Gainsford, T., et al. 1996. Leptin can induce proliferation, differentiation, and functional activation of hemopoetic cell. Proc Natl Acad Sci USA 93: 14564-8

Gillum, R.F., Ingram, D.D., Makuc, D.M. 1993. White blood cell count, coronary heart disease, and death: the NHANES I Epidemiologic Follow-up Study. Am Heart J 125: 85563

Gruden, G., Cavallo-Perin, P., Bazzan, M., Stella, S., Vuolo, A., Pagano, G. 1994. PAI-1 and factor VII activity are higher in IDDM patients with microalbuminuria. Diabetes Care 43: 4269

Guha, M., et al. 2000. Molecular mechanisms of tumor necrosis factor alpha gene expression in monocytic cells via hyperglycemia-induced oxidant stress-dependent and

independent pathways. J Biol Chem 275: 17728-39

Guntur, A. 2006. Perkembangan Imunopathobiogenesis pada SIRS dan Sepsis. SIRS & SEPSIS, Imunologi, Diagnosis, Penatalaksanaan. Surakarta: Sebelas Maret University Press


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