EKSPRESI INTERLEUKIN-1 (IL-1) Β PADA ENDOMETRIOSIS, KARSINOMA ENDOMETRIOID DAN KARSINOMA SEROSUM OVARIUM

Nadia Nur Lestari, Siti Amarwati, Udadi Sadhana, Dik Puspasari

DOI: https://doi.org/10.23917/biomedika.v8i1.3016

Abstract

Endometriosis ovarium memiliki resiko keganasan epithelial ovarium (resiko relatif 1.9 sampai 4.2). Karsinoma endometrioid adalah salah satu jenis keganasan yang paling sering berhubungan dengan endometriosis, sementara karsinoma serosum merupakan keganasan epitelial terbanyak pada ovarium.Serum sitokin pro-inflamasi interleukin-1 (IL-1) β telah ditemukan berperan pada endometriosis dan karsinogenesis.
Penelitian Keita, 2010, menemukan bahwa karsinoma endometrioid memiliki kadar IL-1β yang lebih tinggi secara bermakna dibandingkan jenis lainnya. Penelitian ini bertujua untuk mengetahui perbedaan ekspresi IL-1β pada jaringan endometriosis, karsinoma endometrioid dan karsinoma serosum ovarium. Desain penelitian ini adalah cross sectional design. Sampel adalah tiga puluh 33 blok parafin yang telah didiagnosis dan dire-evaluasi sebagai endometriosis (kelompok A), karsinoma endometrioid (kelompok B) dan karsinoma serosum ovarium (kelompok C) dan dilakukan pemeriksaan imunohistokimia IL-1β. Data ekspresi IL-1β dianalisis uji One Way ANOVA, dilanjutkan dengan uji beda rerata Post Hoc. Hasil uji One Way ANOVA kelompok A, B dan C, p = 0,037, menunjukkan adanya perbedaan bermakna. Uji beda rerata Post Hoc didapatkan kelompok A vs kelompok B dan C (p = 0,034 dan p = 0,020) bermakna. Sedangkan kelompok B vs kelompok C (p =0,805) tidak bermakna. Dari penelitian ini dapat disimpulkan terdapatperbedaan yang bermakna ekspresi IL-1β antara endometriosis dengan karsinoma endometrioid dan karsinoma serosum ovarium, namun tidak terdapat perbedaan yang bermakna ekspresi IL-1β antara karsinoma endometrioid ovarium dan karsinoma serosum ovarium.
Kata kunci: Endometriosis, interleukin-1β, karsinoma endometrioid, karsinoma serosum

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