PROFIL KOAGULASI PASIEN PENDERITA DIABETES MELLITUS DI RS X, KEBUMEN, JAWA TENGAH

Ester Tri Rahayu(1*), Adika Zhulhi Arjana(2), Juwariyah Juwariyah(3), Utami Mulyaningrum(4), Rozan Muhammad Irfan(5)

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(*) Corresponding Author

Abstract

Ulkus diabetes mellitus (DM) adalah komplikasi dari diabetes mellitus yang menimbulkan dampak sosioekonomi yang besar. Morbiditas yang ditimbulkan cukup besar dan secara epidemiologi penderita DM memiliki resiko 25 % untuk terjadinya ulkus DM. Secara patofisiologinya, ulkus DM terjadi atas 3 kondisi yaitu neuropathy, gangguan vaskular, dan infeksi. Gangguan vaskular yang terjadi dimungkinkan disebabkan karena adanya gangguan dalam proses koagulasi. Penelitian ini bertujuan untuk mengetahui kondisi koagulasi pasien DM penderita ulkus DM. Penelitian ini menggunakan data sekunder rekam medis. Subyek yang masuk dalam penelitian ini adalah penderita dewasa ulkus DM. Data rekam medis subyek mengenai kondisi diabetes dan ulkus DM diambil peneliti dan dianalisis secara deskriptif. Hasil penelitian menunjukkan adanya perbedaan yang bermakna pada waktu pembekuan dan kadar SGOT pada berbagai derajat ulkus diabetikum. Akan tetapi perbedaan tidak dijumpai pada waktu perdarahan dan kadar SGPT.

 

Kata Kunci: Ulkus, koagulasi, diabetes mellitus

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References

Abougalambou, S.S.I., Abougalambou, A.S., Sulaiman, S.A.S. & Hassali, M.A., 2012. Prevalence of hypertension, control of blood pressure and treatment in hypertensive with type 2 diabetes in Hospital University Sains Malaysia. Diabetes & metabolic syndrome, 5(3): 115–9.

Beaney, A.J., Nunney, I., Gooday, C. & Dhatariya, K., 2016. Factors determining the risk of diabetes foot amputations – A retrospective analysis of a tertiary diabetes foot care service. Diabetes Research and Clinical Practice, 114: 69–74.

Boulton, A.J., Vileikyte, L., Ragnarson-Tennvall, G. & Apelqvist, J., 2005. The global burden of diabetic foot disease. The Lancet, 366(9498): 1719–1724.

Choucair, J.E., 2016. Epidemiology of diabetic foot infection in a tertiary care hospital in Beirut. International Journal of Infectious Diseases, 53(2016): 75.

Djahmi, N., Messad, N., Nedjai, S., Moussaoui, A., Mazouz, D., Richard, J.L., et al., 2013. Molecular epidemiology of staphylococcus aureus strains isolated from inpatients with infected diabetic foot ulcers in an Algerian University Hospital. Clinical Microbiology and Infection, 19(9): .E398–E404.

Duhon, B.M., Hand, E.O., Howell, C.K. & Reveles, K.R., 2016. Retrospective cohort study evaluating the incidence of diabetic foot infections among hospitalized adults with diabetes in the United States from 1996-2010. American Journal of Infection Control, 44(2): 199–202.

González, F.J.C., Alramadan, M., Matesanz, M., Diaz, A., González-Romo, F., Candel, I., et al., 2003. Infections in diabetic foot ulcers. European journal of internal medicine, 14(5):.341–343.

Hu, Y., Bakhotmah, B.A., Alzahrani, O.H., Wang, D., Hu, F.B. & Alzahrani, H.A., 2014. Predictors of diabetes foot complications among patients with diabetes in Saudi Arabia. Diabetes Research and Clinical Practice, 106(2): 286–294.

Jelinek, H.F., Stranieri, A., Yatsko, A. & Venkatraman, S., 2016. Data analytics identify glycated haemoglobin co-markers for type 2 diabetes mellitus diagnosis. Computers in Biology and Medicine, 75: 90–97.

Jhamb, S., Vangaveti, V.N. & Malabu, U.H., 2016. Genetic and molecular basis of diabetic foot ulcers: Clinical review. Journal of Tissue Viability.25(4): 229-236

Kalani, M., Silveira, A., Blombäck, M., Apelqvist, J., Eliasson, B., Eriksson, J.W., et al., 2007. Beneficial effects of dalteparin on haemostatic function and local tissue oxygenation in patients with diabetes, severe vascular disease and foot ulcers. Thrombosis Research, 120(5): 653–661.

Kasper, D.L., Fauci, A.S., Longo, D.L., Braunwald, E., Hauser, S.L. & Jameson, J.L., 2005. Harrison’s Principles of Internal Medicine 16th ed., The McGraw-Hill Companies.

Lobmann, R., Achwerdov, O., Brunk-Loch, S., Engels, G., Trocha, A., Groene, C., et al., 2014. The diabetic foot in Germany 2005-2012: Analysis of quality in specialized diabetic foot care centers. Wound Medicine, 4, : 27–29.

Navarro-Peternella, F.M., Lopes, A.P.A.T., de Arruda, G.O., Teston, E.F. & Marcon, S.S., 2016. Differences between genders in relation to factors associated with risk of diabetic foot in elderly persons: A cross-sectional trial. Journal of Clinical and Translational Endocrinology, 6: 30–36.

Noor, S., Khan, R.U. & Ahmad, J., 2016. Understanding Diabetic Foot Infection and its Management. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. S1871-4021(16): 30129-1.

Peled, E., Melamed, E., Portal, T.B., Axelman, E., Norman, D., Brenner, B., et al., 2016. Heparanase procoagulant activity as a predictor of wound necrosis following diabetic foot amputation. Thrombosis Research, 139: 148–153.

Perez-Zabala, E., Basterretxea, A., Larrazabal, A., Perez-del-Pecho, K., Rubio-Azpeitia, E. & Andia, I., 2016. Biological approach for the management of non-healing diabetic foot ulcers, 25(2):157-63

Rafehi, H., El-Osta, A. & Karagiannis, T.C., 2012. Epigenetic mechanisms in the pathogenesis of diabetic foot ulcers. Journal of Diabetes and its Complications, 26(6): .554–561.

Versteeg, H.H., Heemskerk, J.W.M., Levi, M. & Reitsma, P.H., 2013. New fundamentals in hemostasis. Physiological reviews, 93(1): 327–58.

DOI: 10.23917/biomedika.v9i1.4345

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