Juwita Raditya Ningsih, Tetiana Haniastuti, Juni Handajani



Gingival epithelium has an important role in the protection of the gingival tissue from mechanical, physical, and chemical trauma also microbial invasion. Re-epithelialization is an important phase of post extraction socket healing. Previous study showed that banana (Musa sapientum L) latex containing tanin, saponin, flavanoid, vitamin C, and minerals i.e: kalium, magnesium, calcium induced re-epithelialization in skin wounds. The objective of the present research was to study the effectivity of banana latex gel in the re-epithelialization of post extraction socket in guinea pigs (Cavia cobaya).

Fifty four guinea pigs were divided into 3 groups, there were negative control group, positive control group and banana latex gel group. Each group consisted of 18 guinea pigs. Mandibular left central incisive were extracted and CMC-Na 1% (negative control), iod-glycerin (positive control) and banana latex gel were applied into the wound socket. Guinea pigs were then sacrified at 1,3,5,7,14,24 day post extraction and processed for histological examination. The specimens were stained with hematoxilin eosin. Epithelial thickness was measured with optilab (µm).

The result of Anova showed significant differences in epithelial thickness among groups (p<0,05). Least Significant of Difference test showed significant differences (p<0,05) at 3,5,7,14,24 day post extraction between banana latex gel group compared to negative control group and also at 7 and 24 day post extraction between banana latex gel group compared to positive control group. In conclusion, banana latex gel may induce re-epithelialization of post extraction socket. The effect of banana latex gel is similar to iod-glycerin.

Key words: re-epithelialization, banana  latex  gel, tooth socket


re-epithelialization, banana latex gel, tooth socket

Full Text:



Steiner, G.G., Francis, W., Burrell, R., Kallet, M.P., Steiner, D.M., and Macias, R., 2008, The Healing Socket and Socket Regeneration. Compendium, 29 (2): 2-11.

Sukotjo, C., Abanmy, A.A., Ogawa, T., and Nishimura, I., 2002. Molecular Cloning of Wound Inducible Transcript (wit 3.0) Differentially Expressed in Edentulous Oral Mucosa Undergoing Tooth Extraction Wound-healing, J Dent Res, 81: 229.

Milloro, M., 2004, Peterson’s Principles of Oral and Maxillofacial Surgery, 2nd ed., Mosby, St.Louis, p. 1-15.

Garrant, P.R., 2003, Oral Cells and Tissues, Quintessence Pub., London, p.81-8, 125-32.

Soelistiono, H., 2008, Analgesics in Dental Pain (Clinical Review), Indonesia Association of Oralmaxillofacial Surgeon,, 22/09/2010.

Rosita, S.M.D., Rostiana, Otih, Pribadi, E.R., dan Hernani, 2007, Penggalian IPTEK Etnomedisin di Gunung Gede Pangrango, Balai Penelitian Tanaman Obat dan Aromatik, Bul Littro. 18(1): 13-28.

Priosoeryanto, B.P., Huminto, H., Wientarsih, I., dan Estuningsih, S., 2006, Aktivitas Getah Batang Pohon Pisang dalam Proses Persembuhan Luka dan Efek Kosmetiknya pada Hewan (Abstr.), Lembaga Penelitian dan Pemberdayan Masyarakat. Institut Pertanian Bogor, 123456789/6081?mode=full, 10/8/2010.

Argawal, P.K., Singh, A., Gaurav, K., Goel, S., Khanna, H.D., and Goel, R.K., 2008, Evaluation of Healing Activity of Extracts Plantain Banana (Musa sapientum var paradisiaca) in Rats, Indian J Exp Biol, 47: 32-40.

Aryenti, 2008, Pengaruh Pemberian Getah Pisang Ambon (Musa paradisiaca var sapientum Lamb) terhadap Penyembuhan Luka Bakar Tikus Putih (Rattus novergicus), Tesis, Pasca Sarjana Fakultas Kedokteran UGM, Yogyakarta.

Tsuchiya, H., Sato, M., Miyazaki T., Fujiwara, S., Tanigaki, S., Ohyama, M., Tanaka, T., and Linurna, S., 1996, Comparative Study on the Antibacterial Activity of Photochemical Flavanones Against Methicilin Resistant Staphylococcus aureus, J Ethnopharmacol, 50:27-30.

Hakkinen, L., Uitto, V., and Larjava, H., 2000, Cell Biology of Gingival Wound Healing, Periodontol 2000, 24(1): 127-152.

Getie, M., Gebre, M.T., Reitz, R., Neubert, R.H., 2002, Evaluation of The Realese Profiles of Flavanoids from Topical Formulation of Crude Extract of Leaves of Dodonea viscose (Sapindaceae), Pharmazie, 57: 320-2.

Bartold, P.M., Walsh, L.J., and Narayanan, A.S., 2000, Molecular and Cell Biology of The Gingiva, Periodontol 2000, 24: 28-55.

Amler, M.H., 1999, Disturbed Healing of Extraction Wound, J Oral Implantol, 25 (3): 179-84.

Nayak, B.S., Sandiford, S., Maxwell, A., 2009, Evaluation of The Wound Healing Activity of Ethanolic Extract of Morinda citrifolia L. leaf, Evid-based Compl Alt, 6 (3): 351-6.

Alzwar. 2009. Berkenalan dengan Aloe Vera,, 1/6/2009.

Kumar, V., Cotran, R.S., Robbins, S.L., 2004, Buku Ajar Patologi (terj.), edisi 7, EGC, Jakarta, h.1-84.

MacKay, D. and Miller, A.L., 2003. Nutritional Suppor for Wound Healing, Altern Med Rev, 8(4): 359-77.

Anonim, 2010, Diet and Nutrition, corpsman-pt3.pdf, 5/12/2010.

Matekaire, T., Mupangwa, J.F., and Kanyamura, E.F., 2005, The Efficacy of Banana Plant (Musa paradisiaca) as a Coccidiostat in Rabbits, Intern J Appl Res Vet Med, 3(4): 326-31.

Fennema, O. R., Karen, M., and Lund, D.B., 1996, Principle of Food Science. The AVI Publ., Connecticut, p. 112-26.

Ramesh, H.A., Azmathulla, M., Baidya, M., and Asad, M., 2010, Wound Healing Activity of Human Urine in Rats, RJPBC, 1(3):750-8.

Diehr, S., Hamp, A., Jamieson, B., 2007, Do Topical Antibiotics Improve Wound Healing?, J Fam Practice, 56(2): 140-4.

Article Metrics

Abstract view(s): 51 time(s)
PDF: 56 time(s)


  • There are currently no refbacks.