Optimasi Formulasi Esens Sheet Mask Kombinasi Ekstrak Spirulina platensis dan Nanopartikel Bentonit dengan Metode Simplex Lattice Design

Erindyah Retno Wikantyasning(1*), Ulil Fikri Nurhakimah(2), Ramadhani Dwi Sula(3), Kartika Fidi Astuti(4)

(1) (SCOPUS ID: 57021971200) Faculty of Pharmacy, Universitas Muhammadiyah Surakarta
(2) Fakultas Farmasi, Universitas Muhammadiyah Surakarta
(3) Fakultas Farmasi, Universitas Muhammadiyah Surakarta
(4) Fakultas Farmasi, Universitas Muhammadiyah Surakarta
(*) Corresponding Author

Abstract

Spirulina platensis contained phycocyanin that has the potential for antioxidant activity. Bentonite contains various minerals that can absorb water and was known having ability for scavenging of free radicals. The purpose of this study was to obtain the optimum formulae of sheet mask essence, containing combination of Spirulina platensis extract and bentonite nanoparticles and evaluated the antioxidant activity using DPPH (2,2-diphenyl-1-pikrihidrazil) assay. Bentonite nanoparticles was prepared by High Energy Milling (HEM) method and characterized using Particle Size Analyzer (PSA). The results of the nanoparticles characterization was 152,8±0,69 nm for the particle size and 0.106±0.03 for PI value. Physical stability tests showed that the formula was homogenous, viscosity between 0.7-1.1 dPas, and pH between 5-6.5. The IC50 value of Spirulina platensis extract was 256.46 ppm with AAI category was medium. The antioxidant test of this fomula that contain Spirulina platensis extract and bentonite nanoparticles did not show any potential antioxidant activity. The concentrations of PEG 400 and Tween 80 were used to formulate the optimum formula were 4.29% w/w and 6.71% w/w.

Keywords

antioxidants; bentonite nanoparticles; optimation; sheet mask essence; spirulina

Full Text:

PDF

References

Al-Zubaidi N.S., Alwasiti A.A. and Mahmood D., 2017, A comparison of nano bentonite and some nano chemical additives to improve drilling fluid using local clay and commercial bentonites, Egyptian Journal of Petroleum, 26 (3), 811–818.

Bashandy S.A.E., El Awdan S.A., Ebaid H. and Alhazza I.M., 2016, Antioxidant Potential of Spirulina platensis Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats, Oxidative Medicine and Cellular Longevity, 2016

Birben E., Sahiner U.M., Sackesen C., Erzurum S. and Kalayci O., 2012, Oxidative Stress and Antioxidant Defense, WAO Journal, 9–19.

Calleja-Agius J., Muscat-Baron Y. and Brincat M.P., 2007, Skin ageing, Menopause Int, 13 (2), 60–64.

Da’i M. and Triharman F., 2010, Uji Aktivitas Penangkap Radikal DPPH (1,1-difenil-2-pikrilhidrazil) Isolat Alfa Mangostin Kulit Buah Manggis (Garcinia mangostana L.), , 11 (2), 47–50.

Krisnawan A., 2009, Karakterisasi Sampel Paduan Magnesium Jenis Az9 1D Dengan Berbagai Variasi Waktu Milling Menggunakan X-Ray Fluoresence (Xrf) Dan X-Ray Difraction (Xrd) Program Studi Fisika Fakultas Sains Dan Teknol Ogi Universitas Islam Negeri Syarif Hidayatullah Jakarta 2009,

Nagpal K., Singh S.K. and Mishra D.N., 2010, Chitosan Nanoparticles: A Promising System in Novel Drug Delivery, Chemical & Pharmaceutical Bulletin, 58 (11), 1423–1430.

Rahmawanty D., Yulianti N. and Fitriana M., 2015, Formulasi dan Evaluasi Masker Wajah Peel Off Mengandung Kuersetin dengan Variasi Konsentrasi Gelatin dan Gliserin, Media Farmasi, 12 (1), 17–32.

Scherer R. and Godoy H.T., 2009, Antioxidant activity index (AAI) by the 2,2-diphenyl-1-picrylhydrazyl method, Food Chemistry, 112 (3), 654–658.

Shalaby E. and Shanab S., 2013, Comparison of DPPH and ABTS assays for determining antioxidant potential of water and methanol extracts of Spirulina platensis, Indian J. Geo-Mar. Sci

Sirait M., Bukit N. and Siregar N., 2017, Preparation and characterization of natural bentonite in to nanoparticles by co-precipitation method, Dalam p. 020006.

Suryani S., Nafisah A. and Mana’an S., 2017, Optimasi Formula Gel Antioksidan Ekstrak Etanol Buah Bligo ( Benincasa hispida ) dengan Metode Simplex Lattice Design ( SLD ), , 3 (2), 150–156.

Suzery M., Lestari S. and Cahyono B., 2012, Penentuan Total Antosianin Dari Kelopak Bunga Rosela (Hibiscus sabdariffa L.) dengan Metode Maserasi dan Sokhletasi, Jurnal Sains & Matematika, 18, 1–6.

DOI: 10.23917/pharmacon.v16i1.8307

Article Metrics

Abstract view(s): 1988 time(s)
PDF: 6978 time(s)

Refbacks

  • There are currently no refbacks.