Email this article UTILISASI INDEKS TROMBOSIT SEBAGAI PREDIKTOR KEPARAHAN PADA KASUS FEBRIS CURIGA DEMAM DENGUE
Adika Zhulhi Arjana(1), Rahma Yuantari(2*), Ninda Devita(3), Rozan Muhammad Irfan(4)(1) Fakultas Kedokteran, Universitas Islam Indonesia
(2) Fakultas Kedokteran Universitas Islam Indonesia
(3) Fakultas Kedokteran Universitas Islam Indonesia
(4) Fakultas Kedokteran Universitas Islam Indonesia
(*) Corresponding Author
Abstract
ABSTRAK
Indeks trombosit memiliki karakteristik yang mengarah pada kondisi cairan dan trombosit tubuh. Penelitian mengenai hubungan indeks trombosit pada penentuan derajat keparahan demam dengue membuka peluang menjadikan indeks trombosit sebagai factor prognostik. Tujuan penelitian ini untuk mngetahui hubungan indeks trombosit sebagai prediktor keparahan pada kasus febris curiga demam dengue. Penelitian ini bersifat non eksperimental analitik. Data diambil dengan metode cohort prospektif. Subjek penelitian adalah pasien febris curiga dengue di RS X, Y, dan Z Yogyakarta dan sekitarnya. Subjek kemudian diambil darah untuk diperiksa indeks trombosit pada saat masuk dan hari ketiga perawatan. Penentuan derajat keparahan dengue dinilai pada hari ketiga perawatan. Hubungan antara hasil indeks trombosit dengan diagnosis dianalisis dengan ANOVA sedangkan korelasi antara indeks trombosit saat admisi dan hari ketiga dengan uji korelasi dengan bantuan software Medcalc. Sebanyak 56 subyek masuk dalam penelitian). Analisis ANOVA menunjukkan adanya perbedaan yang signifikan untuk mean platelet volume (MPV) dan platelet distribution width (PDW) antar derajat infeksi dengue (p=0.01 dan p=0.017). Analisis ANOVA untuk plateocrit menunjukkan tidak ada perbedaan yang signifikan (p=0.055). Uji korelasi hasil antar indeks trombosit menunjukkan hubungan yang signifikan. Adanya perbedaan MPV dan PDW pada berbagai derajat infeksi dengue sehingga dapat digunakan untuk memprediksi keparahan infeksi dengue.
Kata Kunci: Dengue, Indeks Trombosit, Resusitasi Cairan
ABSTRACT
Platelet index has characteristics that lead to the condition of body fluids and platelets. Study on relationship of platelet index in the determining severity of dengue fever opens the opportunity to make the platelet index as a prognostic factor. The aim of this study was to know the correlation of platelet index with predictors of severity of febrile suspected dengue fever. This study was non-experimental and cohort prospective study. The subjects were febrile patients suspicious of dengue in X, Y, and Z Hospital in Yogyakarta and surrounding areas. Subjects were collected blood sample to be examined for platelet index at admission and third day after. Severity of dengue was assessed on third day after admission. Relationship between platelet index with severity was analyzed by ANOVA while correlation between platelet index was analyzed by correlation test with Medcalc software. A total of 56 subjects were included in the study. ANOVA analysis showed a significant difference in mean platelet volume (MPV) and platelet distribution width (PDW) between the degrees of dengue infection (p= 0.01 and p= 0.017). ANOVA analysis for plateocrit showed no significant difference (p = 0.055). Correlation test results between platelet indices show a significant relationship. The results of this study indicate differences in MPV and PDW in various degrees of dengue infection so that it can be used to predict severity of dengue fever.
Keywords: dengue, platelet index, fluid resuscitation
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Alhaeli, A., Bahkali, S., Ali, A., Househ, M.S. and El-Metwally, A.A. 2016. The epidemiology of Dengue fever in Saudi Arabia: A systematic review. Journal of Infection and Public Health, 9(2), pp.117–124.
Bashir, A.B., Saeed, O.K., Mohammed, B.A., and Ageep, A.K. 2015. Role of Platelet Indices in Patients with Dengue Infection in Red Sea State , Sudan. International Journal of Science and Research (IJSR), 1(4), pp.1573–1576.
Beaulieu, L.M. and Freedman, J.E. 2010. The role of inflammation in regulating platelet production and function: Toll-like receptors in platelets and megakaryocytes. Thrombosis Research, 125(3), pp.205–209.
Becchi, C., Al Malyan, M., Fabbiri, L., Marsili, M., Boddi, V. and Boncinelli, S. 2006. Mean Platelet Volume Trend in Sepsis: is it a useful parameter? Minnerva Anestesiol, 72, pp.749–756.
Budak, Y.U., Polat, M. and Huysal, K. 2016. The use of platelet indices, plateletcrit, mean platelet volume and platelet distribution width in emergency non-traumatic abdominal surgery: a systematic review. , (3), pp.178–193.
Ditjen PP dan PL, K.K.R. 2015. Demam Berdarah Biasanya Mulai Meningkat di Januari. Kementrian Kesehatan Republik Indonesia.
Ekber, A., Çevik, Y. and Emektar, E. 2018. Turkish Journal of Emergency Medicine Analysis of mean platelet volume and red blood cell distribution width in recurrent epistaxis. , 18.
Elsayed, A.M. and Mohamed, G.A. 2016. Mean platelet volume and mean platelet volume/platelet count ratio as a risk stratification tool in the assessment of severity of acute ischemic stroke. Alexandria Journal of Medicine. Volume 53. Pp= 67-70
Gunawan, S., Sutanto, F.C., Tatura, S.N.N., Mantik, M.F.J., 2010. Platelet Distribution Width dan Mean Platelet Volume: Hubungan dengan Derajat Penyakit Demam Berdarah Dengue. Sari Pediatri, 12(2).
Muhammad, I., Khan, J., Iqbal, H., Rahman, H. and Muhammad, A. 2016. Seroprevalence and epidemiological status of dengue viral infection in remote areas of Pakistan. Asian Pacific Journal of Tropical Disease, 6(10), pp.776–777.
Pone, S.M., Hökerberg, Y.H.M., de Oliveira, R. de V.C., Daumas, R.P., Pone, T.M., Pone, M.V. da S. and Brasil, P. 2015. Clinical and laboratory signs associated to severe dengue disease in hospitalized children. Jornal de Pediatria, 92(5), pp.464–471.
Prakash, G.M., Anikethana, G. V, Gm, P., Adv, I.J. and Aug, M. 2016. Use of mean platelet volume and platelet distribution width in predicting trend in platelet count and bleeding risks in patients of dengue fever. , 3(3), pp.611–613.
Wiwanitkit, V. 2004. Plateletcrit, Mean Platelet Volume, Platelet Distribution Width: Its Expected Values and Correlation With Parallel Red Blood Cell Parameters. Clinical and Applied Thrombosis/Hemostasis, 10(2), pp.175–178.
World Health Organization (WHO). 2011. Comprehensive guidelines for prevention and control of dengue and dengue haemorrhagic fever. WHO
World Health Organization. 2016. Dengue. WHO.
Yilmaz, Z., Eralp, O., and Ilcol, Y.O. 2008. Evaluation of platelet count and its association with plateletcrit, mean platelet volume , and platelet size distribution width in a canine model of endotoxemia. Vet Clin Pathol; 37 (2). Pp.159-63
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