Identification of Anti-Cancer Compounds in Medicinal Plants Using Metabolomic Approaches: A Review

Yani Magfiroh(1*)

(1) Food Technology Postgraduate, Faculty of Agricultural Technology Soegijapranata Catholic University, Pawiyatan Luhur Street IV/I Bendan Duwur, Semarang 50234
(*) Corresponding Author

Abstract

The modern lifestyle despite its comfort has made cancer a second leading public health problem, following cardiovascular disease. As chemotherapeutic has many side effects including resistance, recent attention has focused on plants which may provide a good opportunity for complementary cancer treatment. Several studies have begun to focus on metabolomic research in order to discover the mechanisms of action of diverse medicinal plants, investigate biomarkers, and comprehend cancer progression at metabolic rates. This study aims to analyze and highlight related metabolomic investigations in medicinal plants that demonstrate the potential of biomarker compounds and their processes in cancer disease. The research methodology uses a literature review that is compiled from many connected journals. According to the findings, bioactive substances present in medicinal plants can be used as biomarkers to disrupt the metabolism of enzymes, transporters, and signaling pathways in cancer cells. Utilized analytical platforms include HPLC, GC-MS, FTIR and NMR. Statistical analysis employs the Anova, PCA, and OPLS-DA methods. Finally, we reviewed biomarkers of medicinal plants and metabolomic pathways, with the result that anticancer compounds may exert their activity by various methods affecting DNA replication, cell cycle, migration and apoptosis.The modern lifestyle despite its comfort has made cancer a second leading public health problem, following cardiovascular disease. As chemotherapeutic has many side effects including resistance, recent attention has focused on plants which may provide a good opportunity for complementary cancer treatment. Several studies have begun to focus on metabolomic research in order to discover the mechanisms of action of diverse medicinal plants, investigate biomarkers, and comprehend cancer progression at metabolic rates. This study aims to analyze and highlight related metabolomic investigations in medicinal plants that demonstrate the potential of biomarker compounds and their processes in cancer disease. The research methodology uses a literature review that is compiled from many connected journals. According to the findings, bioactive substances present in medicinal plants can be used as biomarkers to disrupt the metabolism of enzymes, transporters, and signaling pathways in cancer cells. Utilized analytical platforms include HPLC, GC-MS, FTIR and NMR. Statistical analysis employs the Anova, PCA, and OPLS-DA methods. Finally, we reviewed biomarkers of medicinal plants and metabolomic pathways, with the result that anticancer compounds may exert their activity by various methods affecting DNA replication, cell cycle, migration and apoptosis.

Keywords

anti-cancer, biomarkers, medicinal plant, metabolomic, review

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References

Beger, R.D. A review of applications of metabolomics in cancer. Metabolites 2013, 3, 552–574.

Derbal, Y. 2018. The Adaptive Complexity of Cancer. Biomed. Res. Int. 2018, 5837235.

Guo, W., Cao, P., Wang, X., Hu, M., and Feng, Y. 2022. Medicinal Plants for the Treatment of Gastrointestinal Cancers from the Metabolomics Perspective. Frontiers Volume 13 Article 909755.

Hasanpour, M., Iranshahy, M., and Iranshahi, M. 2020. The Application of Metabolomics in Investigating Anti-diabetic Activity of Medicinal Plants. Biomedicine and Pharmacotherapy 128 110263.

J.K. Nicholson, J.C. Lindon. 2008. Metabonomics, Nature 455 1054-1056.

J. Shi, B. Cao, X.-W. Wang, J.-Y. Aa, J.-A. DUan, X.-X. Zhu, G.-J. Wang, C.-X. Liu. 2016. Metabolomics and Its Application to the Evaluation of The Efficacy and Toxicity of Traditional Chinese Herb Medicines, J. Chromatogr. B 1026 204-216.

Kim, A., Ha, J., Cho, Y., Ahn, J., Cheon, C., Kim, S. H., Ko, S.G., Kim, B., 2021.Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug DIscovery. Nutrient 2021, 13, 3801.

Kotheca, R., Takami, A., Espinoza, J.L. 2006. Dietary Phytochemicals and Cancer Chemoprevention: A Review of the Clinical Evidence. Oncotarget. 7, 52517-52529.

Lemjabbar, H., Basbaum, C. 2022. Platelet-Activating Factor Receptor and ADAM10 Mediate Responses to Staphylococcus aureus in Epithelial Cells. Nat. Med. 2022, 8, 41-46.

Martin, T.A., Ye, L., Sanders, A.J., Lane, J., and Jiang, W.G. 2013. Cancer Invasion and Metastasis: Molecular and Cellular Perspective. In Madame Curie Bioscience Database. Austin: Landes Bioscience.

Mentella, M.C., Scaldaferri, F., Ricci, C., Gasbarrini, A., Miggiano, G.A.D. 2019. Cancer and Mediterranean Diet: A Review. Nutrients 2019, 11, 2059.

Moore, S.C.; Playdon, M.C.; Sampson, J.N.; Hoover, R.N.; Trabert, B.; Matthews, C.E.; Ziegler, R.G. A. Metabolomics Analysis of Body Mass Index and Postmenopausal Breast Cancer Risk. JNCI J. Natl. Cancer Inst. 2018, 6, 588–597.

Nusantara, F.J.P., Putri, S.P. 2018. Metabolomik Mikrobiologi. Bunga Rampai Forum Peneliti Muda Indonesia.

Oyonehi, O.R., Oyonehi, A.B., Erhabor, J.O., Matsabisa, G.M., and Oguntibuje, O.O. 2021. Unraveling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics. Molecules 2021, 26, 6541.

R. Luo, D. Fang, P. Chu, H. Wu, Z. Zhang, Z. Tang, Multiple molecular targets in breast cancer therapy by betulinic acid, Biomed. Pharmacother. 84 (2016) 1321–1330.

R. Madsen, T. Lundstedt, J. Trygg. Chemometrics in Metabolomics - a Review in Human Disease Diagnosis, Anal. Chim. Acta 659 23-33.

Sharifi-Rad, J., Ozleyen, A., Boyunegmez, T.T., Oluwaseun, A.C., El Omari, N., Balahabib, A., Taheri Y., Bouyahya, A., Martorell, M., Martins, N., et al. 2019. Natural Products and Synthetic Analogs as a Source of Antitumor Drugs. Biomolecules 2019, 9, 679.

Singh, N., Yadav, S.S. 2022. A Review on Health Benefits of Phenolics Derived from Dietary Spices. Curr. Res. Food Sci. 2022, 5, 1508-1523.

Varghese, E., Liskova, A., Kubatka, P., Mathews, S.S., Busselberg, D. 2020. Anti-Angiogenic Effects of Phytochemicals on miRNA Regulating Breast Cancer Progression. Biomolecules 2020, 10, 191.

Kim, J.; DeBerardinis, R.J. Mechanisms and implications of metabolic heterogeneity in cancer. Cell Metab. 2019, 30, 434–446.

Schmidt, D.R.; Patel, R.; Kirsch, D.G.; Lewis, C.A.; Vander Heiden, M.G.; Locasale, J.W. Metabolomics in cancer research and emerging applications in clinical oncology. CA Cancer J. Clin. 2021, 16, 760–763.

DOI: 10.23917/bioeksperimen.v9i2.23017

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