Email this article DIABETES MELITUS SEBAGAI FAKTOR RISIKO KEPARAHAN DAN KEMATIAN PASIEN COVID-19: META-ANALISIS
Nining Lestari(1*), Burhannudin Ichsan(2)(1) Fakultas Kedokteran, Universitas Muhammadiyah Surakarta
(2) Fakultas Kedokteran Universitas Muhammadiyah Surakarta
(*) Corresponding Author
Abstract
ABSTRAK
COVID-19 merupakan penyakit infeksi saluran nafas akut yang disebabkan oleh Coronavirus tipe SARS-Cov-2. COVID-19 masih menjadi ancaman seluruh dunia karena morbiditas dan mortalitasnya yang tinggi. Tingkat keparahan dan kematian pasien COVID-19 dipengaruhi oleh diabetes melitus, hipertensi, usia dan obesitas. Namun saat ini masih terdapat kontroversi dalam hasil penelitian mengenai faktor komorbid diabetes ellitus tipe 2 (DM tipe 2) pada COVID-19. Penelitian ini bertujuan mengetahui pengaruh antara DM tipe 2 terhadap keparahan dan kematian COVID-19. Artikel diambil dari PubMed, ScienceDirect, Google Scholar, ProQuest, dan Springer Link. Artikel yang dianalisis adalah artikel yang diterbitkan Desember 2019- Agustus 2020, fulltext dengan desain studi observasional, analisis multivariat, dan mencantumkan adjusted odds ratio (aOR). Kata kunci yang dipakai untuk pencarian artikel adalah (Type 2 diabetes mellitus OR diabetic) AND (mortality OR severity) AND (COVID-19 OR Coronavirus OR SARS-CoV-2) AND ("adjusted odds ratio" OR "aOR"). Artikel dikumpulkan dengan diagram PRISMA dan dianalisis dengan Review Manager application 5.4 dengan model analisis random effect. Penelitian ini menganalisis10 artikel dan mendapati bahwa DM tipe 2 meningkatkan keparahan COVID-19 (aOR = 1,15; 95% CI= 1,11-2,15; p= 0,004) meningkatkan kematian COVID-19 (aOR = 1,65; 95% CI = 1,27-2,16; p< 0,001). Kesimpulannya bahwa diabetes melitus tipe 2 meningkatkan risiko keparahan dan kematian pasien COVID-19.
Kata kunci: Diabetes Melitus, Keparahan, Kematian, COVID-19
ABSTRACT
COVID-19 is an acute airway infection caused by Coronavirus (SARS-Cov-2). COVID-19 remains a worldwide threat due to its high morbidity and mortality. The severity and mortality of COVID-19 patients are mainly affected by diabetes mellitus, hypertension, age, and obesity. This study aims to determine the influence of type 2 diabetes mellitus on the severity and mortality of COVID-19. This was a systematic review and meta-analysis. The articles were obtained from PubMed, ScienceDirect, Google Scholar, ProQuest, and Springer Link. The articles were published from December 2019- August 2020, full-text articles with observational study design, multivariate analysis, and (adjusted odds ratio/aOR). Keywords to search for articles were (Type 2 diabetes mellitus OR diabetic) AND (mortality OR severity) AND (COVID-19 OR Coronavirus OR SARS-CoV-2) AND ("adjusted odds ratio" OR "aOR"). Articles collected using the PRISMA diagram and analyzed using Review Manager application 5.4 with a random effect model. Ten studies were included in the meta-analysis. The results showed that Type 2 DM increased the severity of COVID-19 (aOR = 1.15; 95% CI= 1,11-2,15; p = 0,04) and the mortality of COVID-19 (aOR = 1,65; 95% CI = 1,27-2,16; p <0,001). Conclusion: Type 2 diabetes mellitus increased the severity and mortality of COVID-19.
Keywords: Diabetes Mellitus, Severity, Mortality, COVID-19
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ADA. 2014. Diagnosis and classification of diabetes mellitus. Diabetes Care. 37(SUPPL.1). Pp: S81–S90. https://doi.org/10.2337/dc14-S081
Albitar, O., Ballouze, R., Ooi, J., and Sheikh Ghadzi, S. 2020. Risk factors for mortality among COVID-19 patients. Diabetes Res Clin Pract. https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(20)30545-3/abstract
Alkundi, A., Mahmoud, I., Musa, A., Naveed, S., and Alshawwaf, M. 2020. Clinical characteristics and outcomes of COVID-19 hospitalized patients with diabetes in the United Kingdom: A retrospective single centre study. Diabetes Res Clin Pract. 165. 108263. https://doi.org/10.1016/j.diabres.2020.108263
Bornstein, S. R., Rubino, F., Khunti, K., Mingrone, G., Hopkins, D., Birkenfeld, A. L., Boehm, B., Amiel, S., Holt, R. I., Skyler, J. S., DeVries, J. H., Renard, E., Eckel, R. H., Zimmet, P., Alberti, K. G., Vidal, J., Geloneze, B., Chan, J. C., Ji, L., and Ludwig, B. 2020. Practical recommendations for the management of diabetes in patients with COVID-19. The Lancet Diabetes & Endocrinology. 8(6). Pp: 546–550. https://doi.org/10.1016/S2213-8587(20)30152-2
Bravi, F., Flacco, M. E., Carradori, T., Volta, C. A., Cosenza, G., De Togni, A., Martellucci, C. A., Parruti, G., Mantovani, L., and Manzoli, L. 2020. Predictors of severe or lethal COVID-19, including angiotensin converting enzyme inhibitors and angiotensin II receptor blockers, in a sample of infected Italian citizens. PLoS one. 15(6 June)Pp: 1–11. https://doi.org/10.1371/journal.pone.0235248
Cariou, B., Hadjadja, S., Wargny, M., Pichelin, M., Al-Salameh, A., Allix, I., Amadou, C., Arnault, G., Baudoux, F., Bauduceau, B., Borot, S., Bourgeon-Ghittori, M., Bourron, O., Boutoille, D., Cazenave-Roblot, F., Chaumeil, C., Cosson, E., Coudol, S., Darmon, P., … Gourdy, P. 2020. Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study. Diabetologia. 63(8). Pp: 1500–15. https://doi.org/10.1007/s00125-020-05180-x
Chen, Y., Yang, D., Cheng, B., Chen, J., Peng, A., Yang, C., Liu, C., Xiong, M., Deng, A., Zhang, Y., Zheng, L., and Huang, K. 2020. Clinical Characteristics and Outcomes of Patients with Diabetes and COVID-19 in Association with Glucose-Lowering Medication. Diabetes Care. 43(7). Pp: 1399–407. https://doi.org/10.2337/dc20-0660
Cho, S. I., Yoon, S., and Lee, H.-J. 2020. Impact of comorbidity burden on mortality in patients with COVID-19: a retrospective analysis of the Korean health insurance database. https://doi.org/10.21203/rs.3.rs-54298/v1
Fadini, G. P., Morieri, M. L., Boscari, F., Fioretto, P., Maran, A., Busetto, L., Bonora, B. M., Selmin, E., Arcidiacono, G., Pinelli, S., Farnia, F., Falaguasta, D., Russo, L., Voltan, G., Mazzocut, S., Costantini, G., Ghirardini, F., Tresso, S., Cattelan, A. M., … Avogaro, A. 2020. Journal Pre-proofs Newly-diagnosed diabetes and admission hyperglycemia predict COVID-19 severity by aggravating respiratory deterioration. Diabetes Res Clin Pract. https://doi.org/10.1016/j.diabres.2020.108374
Feng, Y., Ling, Y., Bai, T., Xie, Y., Huang, J., Li, J., Xiong, W., Yang, D., Chen, R., Lu, F., Lu, Y., Liu, X., Chen, Y., Li, X., Li, Y., Summah, H. D., Lin, H., Yan, J., Zhou, M., … Qu, J. 2020. COVID-19 with different severities: A multicenter study of clinical features. Am. J. Respir. Crit. Care Med. 201(11). Pp: 1380–88. https://doi.org/10.1164/rccm.202002-0445OC
Gottlieb, M., Sansom, S., Frankenberger, C., Ward, E., and Hota, B. 2020. Clinical Course and Factors Associated with Hospitalization and Critical Illness Among COVID-19 Patients in Chicago, Illinois. https://doi.org/10.1111/ACEM.14104
Guan, W., Liang, W., Zhao, Y., Liang, H., Chen, Z., Li, Y., Liu, X., Chen, R., Tang, C., Wang, T., Ou, C., Li, L., Chen, P., Sang, L., Wang, W., Li, J., Li, C., Ou, L., Cheng, B., … He, J. 2020. Comorbidity and its impact on 1,590 patients with COVID-19 in China: A Nationwide Analysis. MedRxiv. 2020.02.25.20027664. https://doi.org/10.1101/2020.02.25.20027664
Hernandez, D. R., González-Block, M. Á., Romo-Dueñas, D. K., Lima-Morales, R., Hernández-Vicente, I. A., Lumbreras-Guzmán, M., and Méndez-Hernández, P. 2020. Increased Risk of Hospitalization and Death in Patients with COVID-19 and Pre-existing Noncommunicable Diseases and Modifiable Risk Factors in Mexico. Arch. Med. Res. 51(7). Pp: 683–9. https://doi.org/10.1016/j.arcmed.2020.07.003
Hu, B., Guo, H., Zhou, P., and Shi, Z.-L. 2020. Characteristics of SARS-CoV-2 and COVID-19. Nat. Rev. Microbiol. https://doi.org/10.1038/s41579-020-00459-7
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., Cheng, Z., Yu, T., Xia, J., Wei, Y., Wu, W., Xie, X., Yin, W., Li, H., Liu, M., … Cao, B. 2020. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 395(10223). Pp: 497–506. https://doi.org/10.1016/S0140-6736(20)30183-5
IDF. 2019. Worldwide toll of diabetes. https://diabetesatlas.org/en/sections/worldwide-toll-of-diabetes.html
Killerby, M., Link-Gelles, R., Haight, S. C., Schrodt, C. A., England, L., Gomes, D. J., Shamout, M., Pettrone, K., O’Laughlin, K., Kimball, A., Blau, E. F., Burnett, E., Ladva, C. N., Szablewski, C. M., Tobin-D’Angelo, M., Oosmanally, N., Drenzek, C., Murphy, D. J., Blum, J. M., … Wong, K. K. 2020. Characteristics Associated with Hospitalization Among Patients with COVID-19 — Metropolitan Atlanta, Georgia, March–April 2020 Marie. 69(25). Pp: 790–4. https://doi.org/10.15585/mmwr.mm6925e1
Klang, E., Kassim, G., Soffer, S., Freeman, R., and Levin, M. A. 2020. Morbid Obesity as an Independent Risk Factor for COVID‐19 Mortality in Hospitalized Patients Younger than 50. Wiley Online Library. https://onlinelibrary.wiley.com/doi/abs/10.1002/oby.22913
Lee, Y. H. 2019. What s hot? Strengths and Limitations of Meta-Analysis. Korean J Fam Med. Vol. 94, N. https://doi.org/10.3904/kjm.2019.94.5.391
Muniyappa, R., and Gubbi, S. 2020. COVID-19 pandemic,
coronaviruses, and diabetes mellitus. Am J Physiol Endocrinol Metab. 318(5). E736–E741. https://doi.org/10.1152/ajpendo.00124.2020
Nogueira, P. J., de Araújo Nobre, M., Costa, A., Ribeiro, R. M., Furtado, C., Bacelar Nicolau, L., Camarinha, C., Luís, M., Abrantes, R., and Vaz Carneiro, A. 2020. The Role of Health Preconditions on COVID-19 Deaths in Portugal: Evidence from Surveillance Data of the First 20293 Infection Cases. J. Clin. Med. 9(8). https://doi.org/10.3390/jcm9082368
Pinedo-Torres, I., Flores-Fernández, M., Yovera-Aldana, M., Gutierrez-Ortiz, C., Zegarra-Lizana, P., Intimayta-Escalante, C., Moran-Mariños, C., Alva-Diaz, C., and Pacheco-Barrios, K. 2020. Prevalence of Diabetes Mellitus and Its Associated Unfavorable Outcomes in Patients With Acute Respiratory Syndromes Due to Coronaviruses Infection: A Systematic Review and Meta-Analysis. Clin Med Insights Endocrinol Diabetes. 13.117955142096249. https://doi.org/10.1177/1179551420962495
Rajpal, A., Rahimi, L., and Ismail-Beigi, F. 2020. Factors Leading to High Morbidity and Mortality of COVID ‐19 in Patients with Type 2 Diabetes . J Diabetes. https://doi.org/10.1111/1753-0407.13085
Ryan, C., Minc, A., Caceres, J., Balsalobre, A., Dixit, A., Ng, B., Schmitzberger, F., Syed-Abdul, S., and Fung, C. 2020. Predicting severe outcomes in Covid-19 related illness using only patient demographics, comorbidities and symptoms. Am. J. Emerg. Med. https://doi.org/10.1016/j.ajem.2020.09.017
Samrah, S., and Al-Mistarehi, AHW, A. I. 2020. COVID-19 outbreak in Jordan: Epidemiological features, clinical characteristics, and laboratory findings. Elsevier. https://www.sciencedirect.com/science/article/pii/S2049080120302016
WHO. 2016. Executive Summary Global Report On Diabetes. https://apps.who.int/iris/bitstream/handle/10665/204874/WHO_NMH_NVI_16.3_eng.pdf?sequence=1
WHO. 2020a. Coronavirus Disease Situation Report World Health Organization. World Health Organization. 19(May). Pp: 1–17.
WHO. 2020b. WHO COVID-19 Case definition. https://www.who.int/publications/i/item/WHO-2019-nCoV-Surveillance_Case_Definition-2020.2
Wu, J., Zhang, J., Sun, X., Wang, L., Xu, Y., Zhang, Y., Liu, X., and Dong, C. 2020. Influence of diabetes mellitus on the severity and fatality of SARS-CoV-2 (COVID-19) infection. Diabetes Obes Metab. https://doi.org/10.1111/dom.14105
Ye, C., Zhang, S., Zhang, X., Cai, H., Gu, J., Lian, J., Lu, Y., Jia, H., Hu, J., Jin, C., Yu, G., Zhang, Y., Sheng, J., and Yang, Y. 2020. Impact of comorbidities on patients with COVID-19: A large retrospective study in Zhejiang. China. J Med Virol. June. https://doi.org/10.1002/jmv.26183
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., Guan, L., Wei, Y., Li, H., Wu, X., Xu, J., Tu, S., Zhang, Y., Chen, H., and Cao, B. 2020. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet. 395(10229). Pp: 1054–62. https://doi.org/10.1016/S0140-6736(20)30566-3
Zhou, Y., Yang, Q., Chi, J., Dong, B., Lv, W., and L Shen. 2020. Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: A systematic review and meta-analysis. Elsevier. https://www.sciencedirect.com/science/article/pii/S1201971220305725
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