HUBUNGAN JUMLAH TROMBOSIT DENGAN JUMLAH ERITROSIT PADA PASIEN INFEKSI VIRUS DENGUE DI RS X SURAKARTA

Muhammad Alim Abdul Majid Hidayatullah(1*), Riandini Aisyah(2)

(1) 
(2) 
(*) Corresponding Author

Abstract

Supresi sumsum tulang merupakan kondisi yang biasa terjadi pada pasien terinfeksi dengue. Keadaan ini  menyebabkan penurunan hematopoiesis. Secara teoritis, hal ini akan menurunkan jumlah trombosit dan eritrosit dalam darah tepi. Tujuan dari penelitian ini adalah untuk membuktikan korelasi antara jumlah trombosit dan eritrosit pada pasien terinfeksi dengue. Penelitian ini menggunakan analisis korelasi dengan pendekatan cross sectional. Data yang dikumpulkan dari rekam medis pasien sebanyak 40 pasien yang didiagnosis sesuai kriteria diagnostic WHO 2009, diagnosis dikonfirmasi dengan uji serologis, dan usia di bawah 14. Pasien yang memiliki riwayat anemia hemolitik autoimun (AIHA), purpura trombositopenia idiopatik (ITP), anemia, dan riwayat transfusi darah dikeluarkan dari penelitian ini. Kami menggunakan uji korelasi Pearson dengan software untuk menganalisa data. Rerata jumlah trombosit= 95.625 (52,63) 103 /mm3 dan rerata jumlah eritrosit= 4,83 (0,41) 106/mm3 . Uji korelasi Pearson antara jumlah trombosit dan eritrosit diperoleh nilai r= 0,215 dan nilai p= 0,182, sehingga dapat diartikan bahwa tidak terdapat hubungan antara jumlah trombosit dan eritrosit pada pasien yang terinfeksi dengue.

 

Kata Kunci: infeksi virus dengue, trombosit, eritrosit

Full Text:

PDF

References

Angker, M. & Arima, Y., 2011. Male - Female Differences in The Number of Reported Incident Dengue Fever Cases in Six Asian Countries. Western Pacific Surveillance Response J, 2(2), pp. 17-23.

Anwar, B., Hassan, K., Asif, N. & Parveen, R., 2012. Aplastic Anemia Associated with Dengue Fever. Journal of Islamabad Medical & Dental College, Volume 2, pp. 97-8.

Assinger, A., 2014. Platelets and Infection - an Emerging role of Platelets in Viral Infection. Frontiers in Immunology, 5(649).

Back, A. T. & Lundkvist, A., 2013. Dengue viruses - an overview. Infection Ecology and Epidemiology 2013, Volume 3.

Bhatt, S., Gething, PW., Brady, OJ., Messina, JP., Farlow, AW., Moyes, CL., 2013. The Global Distribution and Burden Of Dengue. Nature, Volume 496, pp. 504-7.

Chauhan, S., Naga, VS., Sood, A., Chatterjee, R., Kadu, R., Patel, DV., 2016. Severe Neutropenia in Dengue-look out for Hemophagocytic Lymphohistiocytosis. Open J Clin Med Case Rep, 2(9), pp. 1-6.

Dinkes Jateng., 2014. Profil Kesehatan Provinsi Jawa Tengah Tahun 2014. Semarang: Dinas Kesehatan Provinsi Jawa Tengah.

Ferreira, G. L., 2012. Global Dengue Epidemiology Trends. Rev. Inst. Med. Trop..

Foller, M., Sopjani, M., Koka, S., Gu, S., Mahmud, H., Wang, K., Floride, E., Schleicher, E., Schulz, E., Munzel, T., Lang, F., 2009. Regulation of Erythrocyte Survival by AMP-activated protein kinase. The FASEB Journal, Volume 23, pp. 1072-80.

Ghazhali, M., Intansari, U. & Laksanawati, I., 2013. The Kinetics of White Blood Cells in Acute Dengue Infection. Trop Med J, 3(1), pp. 29-38.

Gomber, S., Ramachandran, VG., Kumar, S., Agarwal, KN., Gupta, P., 2001. Hematological Observations as Diagnostic Markers in Dengue Hemorrhagic Fever - a Reappraisal. Indian Pediatr, Volume 38, pp. 477-81.

Gregory, CJ., Lorenzi, OD., Colon, L., Sepu Iveda Garcia, A., Santiago, LM., 2011. Utility of the Tourniquet Test and the White Blood Cell Count to Differentiate Dengue among Acute Febrile Illnesses in the Emergency Room. PLOS Negl Trop Dis, 5(12).

Haryoto, E., 2008. Spektrum Klinis Demam Berdarah Dengue Pada Anak. Sari Pediatri, 10(3), pp. 145-50.

Hotzz, E., Tolley, ND., Zimmerman, GA., Weyrich, AS., Bozza, FA., 2011. Platelets in Dengue Infection. Haematology, 8(1-2), pp. 33-8.

Hukom, A. O., Warouw, S. M., Memah, M. & Mongan, A. E., 2013. Hubungan Nilai Hematokrit dan Nilai Jumlah Trombosit Pada Pasien Demam Berdarah Dengue. Journal e-Biomedik, 1(1), pp. 707-11.

Jameel, T., Mehmood, K., Mujtaba, G., Choundry, N., Afzal, N., Paul, RF., 2012. Changing Haematological Parameters in Dengue Viral Infections. J Ayub Med Coll Abbottabad, 24(1), pp. 3-6.

Kementrian Kesehatan Republik Indonesia., 2014. Infodatin. Situasi Demam Berdarah Dengue di Indonesia, 22 April, pp. 1-6.

Krishnamurthy, V., Rajashekar, R. & Doreswamy, S. M., 2016. Peripheral Cell Line Suppression in Dengue Infection in Relation to Serological Status. Asian Journal of Medical Sciences, 7(5), pp. 52-5.

Laderoute, KR., Amin, K., Calaoagan, JM., Knapp, M., Le, T., Orduna, J., Foretz, M., Viollet, B., 2006. 5’-AMP-Activated Protein Kinase (AMPK) Is Induced by Low-Oxygen and Glucose Deprivation Conditions Found in Solid-Tumor Microenvironment. Moleculer and Celluler Biology, 26(14), pp. 5336-47.

Loo, M. & Beguin, Y., 1999. The Effect of Recombinant Human Erythropoietin on Platelet Counts Is Strongly. Blood, 93(10), pp. 3286-93.

Morel, Z. & Ramirez, A., 2014. Autoimmune Response in Children With Dengue. Case Reports. Reumatol Clin, 10(4), pp. 257-9.

Murray, N. E. A., Quam, M. B. & Wilder-Smith, A., 2013. Epidemiology of Dengue: Past, Present and Future Prospects. Clinical Epidemiology, Volume 5, pp. 299-309.

Nelson, ER., Tuchinda, S., Bierman, HR., Chulajata, R., 1966. Haematology of Thai Haemorrhagic Fever (dengue). Bull World Health Organ, 35(1), pp. 43-4.

Pizzaro-Torres, D., 2016. Dengue With Severe Plasma Leakage: A New Monitoring Approach. Acta Med Costarric, 58(3), pp. 115-21.

Rasyada, A., Nasrul, E. & Edward, Z., 2014. Hubungan Nilai Hematokrit Terhadap Jumlah Trombosit pada Penderita Demam Berdarah Dengue. Jurnal Kesehatan Andalas, 3(3), pp. 343-7.

Reuter, S. & Lang, D., 2009. Life Span of Monocytes and Platelets: Importance of Interactions. Frontiers in Bioscience, Volume 14, pp. 2432-47.

Rondina, M. & Weyrich, A., 2015. Dengue Virus Pirates Human Platelets. BLOOD, 126(3), pp. 286-7.

Santoso, A. M., 2014. Hubungan Jumlah Trombosit dengan Kadar Hematokrit Pasien Demam Berdarah Dengue (DBD). Surakarta : Universitas Sebelas Maret. Skripsi.

Simon, A., Sutherland, M. & Pryzdial, E., 2015. Dengue Virus Binding and Replication by Platelets. BLOOD, 126(3), pp. 378-85.

Sovannah, T. & Haang, V., 2012. Correlation between Fever and Leukocyte in Dengue Infection, a Clinical Observation. Adv Lab Med Int, 3(1), pp. 9-13.

Sutherland, M., Simon, AY., Serrano, K., Schubert, P., Acker, JP., Pryzdial, ELG., 2016. Dengue Virus Persist and Replictes During Storage of Platelet and Red Blood Cell Units. Transfusion, Volume 56, pp. 1129-37.

Viennet, E., Ritchie, SA., Faddy, HM., Williams, CR., Harley, D., 2014. Epidemiology of Dengue in a High-Income Country: a Case Study in Queensland, Australia. Parasites & Vectors, Volume 7, p. 379.

WHO, 2009. Dengue Guideliness for Diagnosis, Treatment, Prevention, and Control. New ed. Geneva: WHO Press.

Ziello, J., Jovin, I. & Huang, Y., 2007. Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway and Its Potential for Therapeutic Intervention in Malignancy and Ischemia. Yale Journal of Biology and Medicine, 80(2007), pp. 51-60.

DOI: 10.23917/biomedika.v9i2.5846

Article Metrics

Abstract view(s): 3454 time(s)
PDF: 5658 time(s)

Refbacks

  • There are currently no refbacks.