Formulation and Characterization of Gels of Telang Flower Extract (Clitoria Ternatea L) with Variations of Carbopol Concentration and Antioxidant Activity Test Using DPPH Methods

Setyo Nurwaini(1*), Mutiara Nurul Fatimah(2)

(1) Pharmaceutic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy Universitas Muhammadiyah Surakarta
(2) Pharmaceutic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy Universitas Muhammadiyah Surakarta
(*) Corresponding Author

Abstract

Telang flower (Clitoria ternatea L) has antioxidant activity. Formulation in gel form provides convenience in the use of telang flower extract. This study aims to determine the effect of carbopol as a gelling agent on the physical properties of the gel and to determine the antioxidant activity of telang flower extract gel. Telang flower extract was obtained by maceration method. The gel was formulated with 3 variations of carbopol concentration, namely 0.5%, 1% and 2%. Characterization of Clitoria ternatea L. gel includes: organoleptic, homogeneity, pH, viscosity, spreadability and stickiness. Antioxidant activity test of telang flower (Clitoria ternatea L) using DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The gel formulation of telang flower extract (Clitoria ternatea L.) from 3 formulas met the requirements. Gel with 2% carbopol concentration was the gel with the best characteristics: pH 5.82; viscosity 2,666 cP; spreadability 4.33 cm; stickiness 2.2 s. The Antioxidant activity test of telang flower extract gel showed strong category with an IC50 value of 97.72 ppm. Carbopol has an influence on the physical properties of telang flower extract (Clitoria ternatea L) gel and strong antioxidant activity of bay flower extract gel.

Keywords

telang flower; gel; carbopol; antioxidant activity

Full Text:

PDF

References

Adnan J., Karim A. and Wandawati, 2021, Formulasi Gel Ekstrak Daun Mengkudu (Morinda citrifolia L.) Dengan Variasi Carbopol 940 Sebagai Gelling Agent, Jurnal Farmasi Pelamonia, 01 (1), 11–15.

Afifah H. and Nurwaini S., 2019, Uji Aktivitas Antijamur Gel Serbuk Lidah Buaya (Aloe vera L.) Berbasis Carbopol 934 Terhadap Candida albicans dan Trichophyton mentagrophytes, Pharmacon: Jurnal Farmasi Indonesia, 15 (2), 42–51.

Agustin D. and Ismiyati I., 2015, Pengaruh Konsentrasi Pelarut Pada Proses Ekstraksi Antosianin Dari Bunga Kembang Sepatu, Jurnal Konversi, 4 (2), 9.

Ambari Y., Fitri S. and Nurrosyidah I.H., 2021, Uji Aktivitas Antioksidan Masker Gel Peel-off Ekstrak Etanol Kelopak Bunga Rosela (Hibiscus sabdariffa L.) dengan Metode DPPH (1,1-Diphenyl-2-picryhydrazyl), PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), 18 (1), 54.

Andriani D. and Murtisiwi L., 2020, Uji Aktivitas Antioksidan Ekstrak Etanol 70% Bunga Telang (Clitoria ternatea L) dari Daerah Sleman dengan Metode DPPH, Pharmacon: Jurnal Farmasi Indonesia, 17 (1), 70–76.

Apriani S. and Pratiwi F.D., 2021, Aktvitas Antioksidan Ekstrak Bunga Telang (Clitoria Ternatea L.) Menggunakan Metode Dpph (2,2 Dipheny1 1-1 Pickrylhydrazyl), Jurnal Ilmiah Kohesi, 5 (3), 83–89. Terdapat di: https://kohesi.sciencemakarioz.org.

Cahyaningsih E., Yuda P.E.S.K. and Santoso P., 2019, Skrining Fitokimia dan Uji Aktivitas Antioksidan Ekstrak Etanol Bunga Telang (Clitoria ternatea L) dengan Metode Spektrofotometri UV-VIS, Jurnal Ilmiah Medicamento, 5 (1), 51–57. Terdapat di: https://e-journal.unmas.ac.id/index.php/Medicamento/article/view/851.

Eka Valentina F., Saryanti D., Studi DIII Farmasi P., Tinggi Ilmu Kesehatan Nasional S., Jl Solo-Baki Kwarasan I. and Tengah J., 2023, Formulasi Gel Antibakteri Ekstrak Daun Pandan Wangi (Pandanus amaryllifolius Roxb.) Menggunakan Hydroxy Propyl Methyl Cellulose (HPMC) dan Uji Aktivitas terhadap Staphylococcus aureus Formulation of Antibacterial Gel of Pandan Leaf Extract (Pandanus amary, Pharmacon: Jurnal Farmasi Indonesia, 20 (1), 1–9. Terdapat di: http://journals.ums.ac.id/index.php/pharmacon.

Ida N. and Noer F., 2012, Uji Stabilitas Fisik Gel Ekstrak Lidah Buaya ( Aloe vera L .), Majalah Farmasi dan Farmakologi, 16 (2), 79–84.

Imanto T., Prasetiawan R. and Wikantyasning E.R., 2019, Formulation and Characterization of Nanoemulgel Containing Aloe Vera L. Powder, Jurnal Farmasi Indonesia, 16 (1), 28–37. Terdapat di: http://journals.ums.ac.id/index.php/pharmacon.

Jayanti M., Ulfa A.M. and Saputra Yasir A., 2021, The Formulation and Physical Evaluation Tests of Ethanol in Telang Flower (Clitoria ternatea L.) Extract Losio Form as Antioxidant, Biomedical Journal of Indonesia, 7 (3), 2021. Terdapat di: https://doi.org/10.32539/BJI.v7i3.543.

Kusuma T.M., Azalea M., Dianita P.S. and Syifa N., 2018, The effect of the variations in type and concentration of gelling agent to the physical properties of hydrocortisone, Jurnal Farmasi Sains dan Praktis, IV (1), 44–49.

Marpaung A.M., 2020, Tinjauan manfaat bunga telang (clitoria ternatea l.) bagi kesehatan manusia, Journal of Functional Food and Nutraceutical, 1 (2), 63–85.

Molyneux P., 2004, The use of the stable free radical diphenylpicryl-hydrazyl (DPPH) for estimating antioxidant activity, Songklanakarin Journal of Science and Technology, 50 (June 2003), 211–219.

Mudrikatin S.R.E., 2022, Aktivitas Antioksidan dari Ekstrak Daun Telang, Hospital Majapahit, 14 (2), 250–257.

Nurlely N., Rahmah A., Ratnapuri P.H., Srikartika V.M. and Anwar K., 2021, Uji Karakteristik Fisik Sediaan Gel Ekstrak Daun Kirinyuh (Chromolaena odorata L.) dengan Variasi Karbopol dan HPMC, Jurnal Pharmascience, 8 (2), 79.

Phongpaichit S., Nikom J., Rungjindamai N., Sakayaroj J., Hutadilok-Towatana N., Rukachaisirikul V. and Kirtikara K., 2018, Biological activities of extracts from endophytic fungi isolated from Garcinia plants, FEMS Immunology and Medical Microbiology, 51 (3), 517–525.

Putri W.E. and Anindhita M.A., 2022, Optimization of cardamom fruit ethanol extract gel with combination of HPMC and Sodium Alginate as the gelling agent using Simplex Lattice Design, Jurnal Ilmiah Farmasi, 107–120.

Rachmawati D., Stevani H. and Santi E., 2018, Uji Stabilitas Mutu Fisik Sediaan Masker Gel Wajah Dari Ekstrak Daun Belimbing Wuluh (Averrhoa bilimbi L.) Dengan Variasi Konsentrasi Carbopol, Media Farmasi, 14 (1), 77.

Satolom M.R., Yamlean P.V.Y. and Siampa J.P., 2023, Formulation and physical evaluation gel of avocado seed ( Persea Americana Mill .) as antioxidant using carbopol base concentration, Pharmacon, 12 (1), 97–101.

Senja R.Y. and Amelia R., 2018, Formulasi dan Uji Stabilitas Gel Ekstrak Etanol Daun Kemangi (Ocimum sanctum L.) dengan Pembentuk Gel Carbopol 940 Konsentrasi 0.5% & 0.75% dan HPMC, Medimuh, 1 (1), 45–54.

Setiyadi G. and Qonitah A., 2020, Optimasi Masker Gel Peel-Off Ekstrak Etanolik Daun Sirih (Piper Betle L.) dengan Kombinasi Carbomer dan Polivinil Alkohol, Pharmacon: Jurnal Farmasi Indonesia, 17 (2), 174–183.

Shabrina D.R., Nurwaini S., Farmasi F. and Surakarta U.M., 2023, Formulasi dan Evaluasi Fisik Sediaan Spray Gel Tabir Surya Dari Ekstrak Daun Kersen ( Muntingia calabura L .), Ushada: Journal of Pharmacy, 2 (2), 247–256.

Sumule A., Kuncahyo I. and Leviana F., 2020, Optimasi Carbopol 940 dan Gliserin dalam Formula Gel Lendir Bekicot (Achatina fulica Ferr) sebagai Antibakteri Staphylococcus aureus dengan Metode Simplex Lattice Design, PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), 17 (1), 108.

Yusuf A.L., Nugraha D., Wahlanto P., Indriastuti M., Ismail R. and Himah F.A., 2022, Formulasi Dan Evaluasi Sediaan Gel Ekstrak Buah Pare (Momordica Charantia L.) Dengan Variasi Konsentrasi Carbopol 940, Pharmacy Genius, 1 (1), 50–61.

Article Metrics

Abstract view(s): 35 time(s)
PDF: 42 time(s)

Refbacks

  • There are currently no refbacks.