A Systematic Review: Ethnomedicinal Uses And Pharmacological Activity Of Male Papaya Flower (Carica papaya L.)

Purwaningsih Purwaningsih(1), Peni Indrayudha(2*)

(1) Magister of Pharmacy, Universitas Muhammadiyah Surakarta
(2) Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Jl. A. Yani. 157 Pabelan, Sukoharjo, Indonesia
(*) Corresponding Author

Abstract

An extensively utilized plant in traditional medicine is the papaya plant (Carica papaya L.). Papaya plants are useful in almost all parts, one part of (Carica papaya  L.) that has potential is the papaya flowers. Papaya flowers are often used as a vegetable, but papaya flowers also have health benefits. The purpose of this review is to present thorough and current information on the ethnomedical usage and pharmacological activity of male papaya flowers. The search method was carried out using relevant keywords of the following databases: Google Scholar, ScienDirect, and NCBI. The results of the article search after going through the article selection process based on the database resulted in 25 relevant articles. Male papaya flowers contain many bioactive compounds known pharmacological activities, including antioxidant, anticancer, antibacterial, antidiabetic, analgesic, wound healing, antihyperlipidemic, bioinsecticide, tyrosinase inhibition and sun protection activity. This pharmacological activity may be caused by the large number of bioactive compounds contained in male papaya flowers.

Keywords

male papaya flower; ethnomedicine; pharmacology activity

References

Ali, A., Devarajan, S., Waly, M. I., Essa, M. M., & Rahman, M. S. (2012). Nutritional and medicinal values of papaya (Carica papaya L.). Natural Products and Their Active Compounds on Disease Prevention, August, 307–324. https://doi.org/10.20959/wjpps20178-9947

Antari, E. D., Purwaningsih, Septiarini, Dwi, A., Wardani, & Siska, T. (2013). ANALISIS NILAI SPF (Sun Protection Factor) SEDIAAN KRIM TABIR SURYA EKSTRAK ETANOL BUNGA PEPAYA JANTAN (Carica papaya L.) DENGAN METODE SPEKTROFOTOMETRI UV-VIS Ester. NBER Working Papers, 5, 89. http://www.nber.org/papers/w16019

Anugraheni, A., & Rini, C. S. (2023). Effect of Papaya flower ethanolic extract (Carica Papaya) on the time kill of tetracyclin against Escherichia Coli. Pharmaciana, 13(2), 246. https://doi.org/10.12928/pharmaciana.v13i2.24711

Ashish B. Wadekar, Minakshee G. Nimbalwar, Wrushali A. Panchale, Bhushan R. Gudalwar, Jagdish V. Manwar, & Ravindra L. Bakal. (2021). Morphology, phytochemistry and pharmacological aspects of Carica papaya, an review. GSC Biological and Pharmaceutical Sciences, 14(03), 234–248. https://doi.org/10.30574/gscbps.2021.14.3.0073

Bergonio, K. B., & Perez, M. A. (2016). The potential of male papaya (Carica papaya, L.) flower as a functional ingredient for herbal tea production. Indian Journal of Traditional Knowledge, 15(1), 41–49.

Dwivedi, M. K., Sonter, S., Mishra, S., Patel, D. K., & Singh, P. K. (2020). phytochemical characterization of Carica papaya flowers.

Fitriani, D., Rusmini, H., & Marek, Y. W. (2019). PENGARUH PEMBERIAN EKSTRAK BUNGA PEPAYA (Carica papaya L) TERHADAP KADAR HIGH DENSITY LIPOPROTEIN (HDL) DAN LOW DENSITY LIPOPROTEIN (LDL) DARAH TIKUS (Rattus norvegicus) GALUR Sprague dawley JANTAN YANG DIBERI DIET TINGGI LEMAK. Jurnal Ilmu Kedokteran Dan Kesehatan, 6(4), 247–256. https://doi.org/10.33024/jikk.v6i4.2293

Halder, S., Dutta, S., & Khaled, K. L. (2022). Evaluation of phytochemical content and in vitro antioxidant properties of methanol extract of Allium cepa, Carica papaya and Cucurbita maxima blossoms. Food Chemistry Advances, 1(September), 100104. https://doi.org/10.1016/j.focha.2022.100104

Hamid, N. K. A., Somdare, P. O., Md Harashid, K. A., Othman, N. A., Kari, Z. A., Wei, L. S., & Dawood, M. A. O. (2022). Effect of papaya (Carica papaya) leaf extract as dietary growth promoter supplement in red hybrid tilapia (Oreochromis mossambicus × Oreochromis niloticus) diet. Saudi Journal of Biological Sciences, 29(5), 3911–3917. https://doi.org/10.1016/j.sjbs.2022.03.004

Hidayati, T. K., Susilawati, Y., & Muhtadi, A. (2020). KEGIATAN FARMAKOLOGIS DARI BERBAGAI BAGIAN Carica papaya Linn. EKSTRAK: BUAH, DAUN, BENIH, UAP, KULIT DAN AKAR. Jurnal Riset Kefarmasian Indonesia, 2(3), 211–226. https://doi.org/10.33759/jrki.v2i3.97

Iskandar, I., Horiza, H., & Bahri, S. (2020). Efektifitas Ekstrak Bunga Pepaya (Carica papaya) sebagai Bioinsektisida terhadap Kematian Lalat di TPA Ganet, Kota Tanjungpinang. Sanitasi: Jurnal Kesehatan Lingkungan, 11(1), 14–19. https://doi.org/10.29238/sanitasi.v11i1.932

Le Thao My, P., Van Luc, T., Do Dat, T., Hoai Thanh, V., Khanh Duy, H., Thanh Phong, M., Minh Nam, H., & Huu Hieu, N. (2020). Optimization of Flavonoids Extraction from Vietnamese Male Papaya (Carica papaya, L.) Flowers by Ultrasound-Asissted Method and Testing Bioactivities of the Extract. ChemistrySelect, 5(42), 13407–13416. https://doi.org/10.1002/slct.202002723

Lien, G. T. K., Van, D. T. T., Cuong, D. H., Yen, P. H., Tai, B. H., & Van Kiem, P. (2019). A New Phenolic Constituent from Carica papaya Flowers and Its Tyrosinase Inhibitory Activity. Natural Product Communications, 14(7). https://doi.org/10.1177/1934578X19850987

Lusiyaningrum, T. A. (2021). UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL BUNGA PEPAYA (Carica papaya L.) DENGAN METODE ABTS (2,2 azinobis (3-etilbenzotiazolin)-6-asam sulfonat) KARYA. In Paper Knowledge . Toward a Media History of Documents (Vol. 3, Issue 2).

Maheswari, U., Sridevi Sangeetha, K. S., Umamaheswari, S., Uma, C., Reddy, M., & Kalkura, S. N. (2016). FLAVONOIDS: THERAPEUTIC POTENTIAL OF NATURAL PHARMACOLOGICAL AGENTS Invitro anti oxidant activity View project Antibiotics View project FLAVONOIDS: THERAPEUTIC POTENTIAL OF NATURAL PHARMACOLOGICAL AGENTS. International Journal of Pharmaceutical Sciences and Research, 7(10), 3924. https://doi.org/10.13040/IJPSR.0975-8232.7(10).3924-30

Manengkey, Karauwan, F. A., & Amal R .Ginting, S. L. T. (2019). Uji Efektivitas Ekstrak Bunga Pepaya Jantan Carica papaya L. Sebagai Analgesik Terhadap Tikus Putih Rattus norvegicus. The Tropical Journal of Biopharmaceutical, 2(2), 158–169.

Marpaung, F. S., Tampubolon, E. J. br, Andika, M. I., Lubis, Y. E. P., & Mutia, M. S. (2021). The effectiveness test of papaya (Carica papaya L.) flower extract on blood sugar level of the sucrose-induced male mice (Mus musculus L.). Biospecies, 14(1), 24–31.

Mukhaimin, I., Saraswati, E. A., Ajizah, R., & Triyastuti, M. S. (2019). Product Quality of Quercetin Extract From Carica Papaya L Flower by Microwave-Assisted Extraction (MAE). Jurnal Rekayasa Kimia & Lingkungan, 14(2), 139–146. https://doi.org/10.23955/rkl.v14i2.14598

Nainggolan, M., & Kasmirul. (2015). Cytotoxicity activity of male Carica papaya L . flowers on MCF-7 breast cancer cells. Journal of Chemical and Pharmaceutical Research, 7(5), 772–775.

Natalia, E., Potensi, B., Teh, S., Bunga, H., Jantan, P., Barung, E. N., Aditia, O., Sasue, A., Kalonio, D. E., Politeknik, J. F., Kementerian, K., & Manado, K. (2023). PROSIDING SEMINAR NASIONAL DIES NATALIS POLTEKKES KEMENKES MANADO XXII TAHUN 2023 304 (Carica papaya L) Dalam Menurunkan Kadar Gula Darah Tikus Putih Terinduksi Fruktosa dan Lemak Potensi Seduhan Teh Herbal Bunga Pepaya Jantan (Carica papaya L) Dalam Menu. 2, 304–308.

Nirmala, S., Arun, S., & Sivanagamoorthi, M. (2012). Research Journal of Pharmaceutical , Biological and Chemical Sciences Antioxidant [ In vitro ] and analgesic activity [ In vivo ] of tannin fraction of stem bark of Ficus racemosa Linn. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 3(1), 597–603.

Okoye, E. I. (2017). Preliminary Pharmaceutical Constituents of Crude Solvent Extracts of Flower and Stalk of Male Carica papaya. Chemistry Research Journal, 2017(1), 20–26. www.chemrj.org

Pongoh, A. F., Queljoe, E. De, & Rotinsulu, H. (2020). UJI ANTIDIABETIK EKSTRAK ETANOL BUNGA PEPAYA (Carica papaya L.) TERHADAP TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI ALOKSAN. Pharmacon, 9(1), 160. https://doi.org/10.35799/pha.9.2020.27423

Santi, L., Beys-Da-Silva, W. O., Berger, M., Calzolari, D., Guimarães, J. A., Moresco, J. J., & Yates, J. R. (2023). Proteomic profile of Cryptococcus neoformans biofilm reveals changes in metabolic processes. Journal of Proteome Research, 13(3), 1545–1559. https://doi.org/10.1021/pr401075f

Santoso, D. S. P. (2020). POTENSI ANTIBIOTIK FRAKSI ETIL ASETAT EKSTRAK ETANOL BUNGA PEPAYA JANTAN (Carica papaya L) TERHADAP BAKTERI Staphylococcus aureus DAN Escherichia Coli. In Malaysian Palm Oil Council (MPOC) (Vol. 21, Issue 1). http://journal.um-surabaya.ac.id/index.php/JKM/article/view/2203%0Ahttp://mpoc.org.my/malaysian-palm-oil-industry/

Sianipar, M. P., Suwarso, E., & Rosidah, R. (2018). Antioxidant and anticancer activities of hexane fraction from Carica Papaya l. Male flower. Asian Journal of Pharmaceutical and Clinical Research, 11(3), 81–83. https://doi.org/10.22159/ajpcr.2018.v11i3.22382

Syafiq, A. F. (2022). AKTIVITAS ANTIOKSIDAN IN VITRO INFUSA BUNGA PEPAYA GANTUNG (Carica papaya L.) DENGAN METODE DPPH (2, 2-diphenyl-1 picrylhidrazil). http://repository.stikesdrsoebandi.ac.id/355/

Talukdar, N., Barchung, S., & Barman, I. (2021). Phytochemical Screening and Study of Total Protein Content , Antimicrobial Activity of the Male Flower of Carica papaya L . Nayan Talukdar , Sutila Barchung and Phytochemical Screening and Study of Total Protein Content , Antimicrobial Activity of the Mal. September, 1540–1542.

Tangkumahat, F. G., Rorong, J. A., & Ftimah, F. (2017). PENGARUH PEMBERIAN EKSTRAK BUNGA DAN DAUN PEPAYA (Carica papaya L.) TERHADAP KADAR GLUKOSA DARAH TIKUS WISTAR (Rattus norvegicus L.) YANG HIPERGLIKEMIK. Jurnal Ilmiah Sains, 17(2), 143. https://doi.org/10.35799/jis.17.2.2017.17681

Van, D. T. T., Cuong, D. H., Lien, G. T. K., & Yen, P. H. (2020). Phytochemical study of the ethyl acetate extract of male Carica papaya flowers from Quang Nam – Da Nang. Vietnam Journal of Chemistry, 58(2), 145–150. https://doi.org/10.1002/vjch.201900029

Vij, T., & Prashar, Y. (2015). A review on medicinal properties of Carica papaya Linn. Asian Pacific Journal of Tropical Disease, 5(1), 1–6. https://doi.org/10.1016/S2222-1808(14)60617-4

Wahyuni, Ilyas, M., & Agusraeni, R. (2018). Uji Potensi Antidiabetik Ekstrak Bunga Pepaya (Carica papaya L.) Terhadap Mencit Jantan Balb/C Yang Diinduksi Streptozocin (STZ). Jurnal Insan Farmasi Indonesia, 1(1), 130–144.

Wantu, M. M. . (2022). PENGARUH GEL EKSTRAK ETANOL BUNGA PEPAYA (Carica Papaya) TERHADAP KONTRAKSI LUKA EKSISI PADA TIKUS PUTIH JANTAN (Rattus norvegicus strain wistar) YANG DIINDUKSI ALOKSAN. Universitas Muhammadiyah Malang.

Wati, D. R. (2022). UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL BUNGA PEPAYA GANTUNG (Carica papaya L.) DENGAN METODE DPPH (2,2-difenil-1-pikrilhidrazil).

Yuliastuti, F. yuliastuti. (2021). Uji Aktivitas Ekstrak Bunga Pepaya Jantan Sebagai Antidiare Terhadap Escherichia Coli. Jurnal Jamu Kusuma, 1(1), 15–20. https://doi.org/10.37341/jurnaljamukusuma.v1i1.1

Yusnita, Y., Masfria, M., Rosidah, R., & Iksen, I. (2018). Effect of hexane fraction from Papaya (Carica papaya L.) male flower on cell cycle of colon adenocarcinoma (widr) cell and its combination index with doxorubicin. Asian Journal of Pharmaceutical and Clinical Research, 11(7), 138–140. https://doi.org/10.22159/ajpcr.2018.v11i7.25023

DOI: 10.23917/pharmacon.v21i0.23474

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