The Antihyperglycemic Effects of Glibenclamide and Matoa Leaves Extract (Pometia pinnata J.R. Forst & G. Forst) On Alloxan-Induced Rat

Muhammad Labib Qotrun Niam(1*), Nur Khalida Ziah(2), Arini Fadhilah(3)

(1) Faculty of Pharmacy, Universitas Muhammadiyah Surakarta Jl Ahmad Yani Kartasura, Surakarta, Indonesia
(2) Faculty of Pharmacy, Universitas Muhammadiyah Surakarta Jl Ahmad Yani Kartasura, Surakarta, Indonesia
(3) Faculty of Pharmacy, Universitas Muhammadiyah Surakarta Jl Ahmad Yani Kartasura, Surakarta, Indonesia
(*) Corresponding Author

Abstract

Glibenclamide (GLI) orally treatment for diabetes mellitus has adverse effects, such as hypoglycemia and weight gain. A synergistic effect achieved through the combination of natural constituents provides an alternative method for reducing adverse effects. The aim of this study was to investigate the contribution of 50% ethanol leaves extract (EEDM) to the administration of GLI in alloxan induced rats. A total of 20 rats were divided into 4 groups, namely normal control (NC), negative control, GLI 5 mg/KgBW group, and the combination of GLI 5 mg/KgBW and EEDM 100 mg/KgBW. Fasting blood sugar data (FBG), body weight, urine chemistry for 15 days of treatment measured. The results show that the ability of the GLI-EEDM combination to lower FBG is more effective and can withstand the hypoglycemic effects of GLI, in addition to improving the secretion of glucose in the urine.

Keywords

Alloxan; Antidiabetic; Glibenclamide; Matoa Leaves

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DOI: 10.23917/pharmacon.v21i0.23665

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