Deteksi Asam Mefenamat pada Jamu Pegel Linu yang beredar di Wilayah Pekalongan

Siska Rusmalina(1*), Kharismatul Khasanah(2), Denny Kurniawan Nugroho(3)

(1) Universitas Pekalongan, Jl. Sriwijaya No. 3 Kota Pekalongan
(2) Universitas Pekalongan, Jl. Sriwijaya No. 3 Kota Pekalongan
(3) Mahasiswa Program Studi D-3 Farmasi Universitas Pekalongan, Jl. Sriwijaya No. 3 Kota Pekalongan, Indonesia
(*) Corresponding Author

Abstract

Jamu Pegel Linu is one of the most popular herbs in Indonesia and oftenly the producers added medicinal chemicals (BKO) so that the resulting therapeutic effect is more effective. One of the BKO added is mefenamic acid. The added content of mefenamic acid can cause harmful side effects such as seizures and can even cause coma. This study aimed to detect the BKO content of mefenamic acid in Jamu Pegel Linu distributed in Pekalongan region. This research was a descriptive study with purposive sampling. The sample used was all Jamu pegel linu that were distributing in Pekalongan region that were included the inclusion and exclusion criteria. The analytical method used is Thin Layer Chromatography (TLC) with a mobile phase in the form of ethyl acetate: methanol: ammonia (80:10:10). Spotting detection was carried out under UV light at λ 254 nm. The results of the spots obtained were compared with a comparison standard. To ensure the results obtained are confirmed using the color reaction method. The results of testing of 27 samples by TLC method obtained there are 3 (three) samples of herbal medicine giving positive results indicated by the similarity of rf values with comparative standards. The results obtained were tested qualitatively with color reagents to strengthen the results.

Keywords

mefenamic acid, thin layer chromatography (TLC), Jamu Pegel Linu

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References

Gandjar, I.G., & Rohman, A. 2007. Kimia Farmasi Analisis. Yogyakarta: Universitas Gadjah Mada

Pine, A.T., Alam, G., Attamin, F. 2011. Standarisasi mutu dan ekstrak daun Gedi (Abelmoschus manihot L) Medik) dan uji efek antioksidan dengan metode DPPH. Makassar, Universitas Hasanuddin.

Ahmad, F.A., 2012, Analisis Penggunaan Jamu untuk Pengobatan Pada Pasien di Klinik Saintifikasi Jamu Hortus Medicus Tawangmangu Tahun 2012, Tesis, 11, Program Pasca Sarjana Ilmu Kesehatan Masyarakat, Fakultas Kesehatan Masyarakat, Universitas Indonesia, Depok.

Auterhoff, H., Kovar, K., 1987, Identifikasi Obat, 32, 98, Penerbit ITB, Bandung.

BPOM R.I., 2006, Bahaya Bahan Kimia Obat (BKO) Yang Dibubuhkan Kedalam Obat Tradisional (Jamu), available at: https://www.pom.go.id/new/view/more/berita/144/BAHAYA-BAHAN-KIMIA-OBAT--BKO--YANG-DIBUBUHKAN-KEDALAM-OBAT-TRADISIONAL--JAMU-.html, 19/11/2019, 20:00:09 WIB.

BPOM R.I., 2009, Public Warning/Peringatan No. KH.00.01.1.43.2397 tanggal 4 Juni 2009 tentang Obat Tradisional dan Suplemen Makanan Mengandung Bahan Kimia Obat, Balai Pengawasan Obat dan Makanan Republik Indonesia, Jakarta.

DepKes R.I., 1979, Farmakope Indonesia, Edisi III, 675, Departemen Kesehatan Republik Indonesia, Jakarta.

Gandjar, I.G., Rohman, A., 2016, Kimia Farmasi Analisis, 1, 353-361, Pustaka Pelajar, Yogyakarta.

Gitawati, R., 2013, Analisis Adulterasi Jamu Pegal Linu yang Diperoleh Dari Pasar Di Jakarta dan Sekitarnya, 269-274, Buletin Penelitian Sistem Kesehatan, Vol. 16 (3).

Hayun, Karina, M.A., 2016 Pengembangan dan Validasi Metode KLT-Densitometri untuk Analisis secara simultan Parasetamol, Asam Mefenamat dan Ibuprofen dalam Jamu ”Pegal Linu”, 152, Jurnal Sains Farmasi & Klinis, Vol. 2 (2).

MenKes R.I., 1994, Persyaratan Obat Tradisional, 4, Menteri Kesehatan Republik Indonesia, Jakarta.

Polakow, A. H., 1916, Studies In Qualitative Organic Analysis, Thesis, 6, College of Liberal Arts and Sciences, University of Illinois, Illinois.

Pharmaceutical Press, 2009, Martindale The Complete Drug Reference, 80, 36th edition, RFS Publication, China.

Riyanti, S., Sutardi, O.I., Ratnawati, J., 2013, Pemantauan Kualitas Jamu Pegal Linu Yang Beredar Di Kota Cimahi, 45-48, Kartika Jurnal Ilmiah Farmasi, 1 (1).

Rusnaeni, Sinaga D.I., Lanuru F., Payungallo, I.M., 2016, Identifikasi Asam Mefenamat dalam Jamu Rematik Yang Beredar di Distrik Heram Kota Jayapura, Papua, 84-91, Pharmacy, Vol. 13 (1).

Sidoretno, W.M., Rz, I.O., 2018, Edukasi Bahaya Bahan Kimia Obat Yang Terdapat Di Dalam Obat Tradisional, 41, Jurnal Pengabdian Masyarakat, Vol. 1 (2).

Wahyuni, A.S., Sujono, T.A., 2004, Studi Aktivitas Daya Analgetik Jamu Pegal Linu, 21-32, Jurnal Penelitian Sains&Teknologi, Vol. 5 (1).

Wonorahardjo, S., 2016, Metode-Metode Pemisahan Kimia Sebuah Pengantar, 103, 127, 186, PT. Indeks, Jakarta.

DOI: 10.23917/pharmacon.v0i0.10111

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