Evaluation of the Use of Antibiotics in Chronic Renal Failure Patients in RSUP Dr. Soeradji Tirtonegoro Klaten Period 2014

Gita Ayu Pradina(1*), Zakky Cholisoh(2)

(1) Universitas Muhammadiyah Surakarta
(2) Universitas Muhammadiyah Surakarta
(*) Corresponding Author

Abstract

Antibiotics are one of the most widely used drugs in curing various kinds of infectious diseases. The use of
antibiotics, especially in chronic renal failure, need to be considered because it can cause nephrotoxicity
in kidneys. The purpose of this study was to evaluate the rational use of antibiotics in RSUP Dr. Soeradji
Tirtonegoro in cases of chronic renal failure in 2014. The evaluation includes the right indication, the
right drug, right patient, and proper dosage. This research is conducted in a manner that is based on a
retrospective medical record belongs to chronic renal failure patients on inpatient RSUP Dr. Tirtonegoro
Klaten 2014. The search results obtained from medical records and evaluation results indicated the use
of appropriate antibiotics as many as 20 cases (55.56%), patients with chronic renal failure who meet the
appropriate criteria are 39 cases (97.7%), use of the right type of antibiotics drugs there were 13 cases
(29,5%), and to use appropriate antibiotics doses were 21 cases (47.7%). Discharge status of patients
with a total of 36 cases (100%) with result of the patient’s health improved. From the result of arithmetic
leukocytes figure, there are 33 cases ( 91.67 % ) with leukocytes count back to normal.

Full Text:

PDF

References

Bayer, A., Erler, M., Gerlach, F.M., Haefeli, W.E., Petersen, J.J., Rath, T., Rochon, J., & Saal,

K., 2012, How to Improve Drug Dosing For Patients With Renal Impairment in Primary

Care - a Clusterrandomized Controlled Trial, Jerman, BMC Family Practice, 13:91.

BMJ, 2009, British Formulari National, GGP Media GmbH, Possneck, Germany.

BPOM., 2013, Lampiran 3: Informatorium Obat Nasional Indonesia, Jakarta, CV Sagung Seto.

Chasani, S., 2008, Antibiotik Nefrotoksik: Penggunaan pada Gangguan Fungsi Ginjal, Laporan

Penelitian, Semarang: Fakultas Kedokteran, Universitas Diponegoro.

Chonchol, M. & Spiegel, D.M., 2009, The Patient with Chronic renal failure, In: Schrier, R.W.,

th ed, Manual of Nephrology, Philadelphia, Lippincott Williams and Wilkins.

Dipiro, T.J., Matzke, G.R., Posey, L.M., Talbert, R.L., Wells, B.G., & Yee, G.C., 2006,

Pharmacotherapy Handbook, Sixty Edition, Mc. Graw Hill.

Feldman, C., Brink, A.J., Richard, G.A., Maartens, G., & Bteman, E.D., 2007, Management of

Community-Acquired Pneumonia in Adult, Afrika, Working Group of the South African

Thoracic Society, 97(12)

Gupta, K., Hooton, T.M., Naber, K.G., Wult, B., Colgan, R., Miller, L.G., Moran, G.J., Nicolle,

L.E., Razz, R., Schaeffer, A.J., & Soper, D.E., 2011, International Clinical Partical

Guidelines for the Treatment of Acute Uncomplicated Cystitis and Pyelonephritis in

Women: A 2010 Update by the Infectious Diseases Society for Microbiology and Infectious

Disease, Boston, Oxford University Press on behalf of the Infectious Diseases Society of

America, 52(5):e103-e120.

Kenward, R. & Tan, C.K., 2003, Penggunaan Obat Pada Gangguan Gagal Ginjal, dalam Aslam

Farmasi Klinis: Menuju Pengobatan Rasional dan Penghargaan Pilihan Pasien 2003,

Jakarta, PT. Elex Media Komputindo Gramedia.

Krejcie, R.V. & Morgan, D.W., 1970, Determining Sample Size for Research Activities.

Educational and Psychological Measurement.

Kunin, C.M., Glazko, A.J. & Finland, W., 1959, Persistence Of Antibiotics in Blood of Patients

With Acute Renal Failure. II. Chloramphenicol and Its Metabolic Products In The Blood

Of Patients With Severe Renal Disease or Hepatic Cirrhosis, Detroit, Mich, Thorndike

Memorial Laboratory, Second and Fourth (Harvard) Medical Services, Boston City

Hospital, and the Department of Medicine, Harvard Medical School, Boston, Mass., and

from the Research Division, Parke, Davis and Company.

Parfati, Budisutio, F.H., & Tan, C.K., 2003, Farmakokinetik Klinis, dalam Aslam Farmasi

Klinis: Menuju Pengobatan Rasional dan Penghargaan Pilihan Pasien 2003, Jakarta,

PT. Elex Media Komputindo Gramedia.

Peraturan Menteri Kesehatan RI nomor: 2406/MENKES/PER/XII/2011, 2011, Pedoman Umum

Penggunaan Antibiotik, Jakarta, Menteri Kesehatan Republik Indonesia.

Yulianti, T., Hakim, L. & Putranto, W., 2007, Evaluasi Penggunaan Antibiotik Pada Pasien

Gagal Ginjal Kronik di RSUD Dr. Moewardi Surakarta Periode September-November

, Tesis, Yogyakarta: Fakultas Farmasi Pasca Sarjana,

http://etd.ugm.ac.id/index.php?mod=review⊂=Review&act=view&typ=html&buku_

id=38187&obyek_id=4&unitid=1&jenis_id (diakses tanggal 20 September 2014)

Article Metrics

Abstract view(s): 349 time(s)
PDF: 998 time(s)

Refbacks

  • There are currently no refbacks.