Cytotoxic Effects of Plant Bioactive Compounds on T47d Breast Cancer Cells Line: A Review

Tio Firmansyah(1), Utami Saraswati(2), Kurniadi Ilham(3), Robby Jannatan(4), rita maliza(5*)

(1) Departemen Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Andalas, Limau Manis, Padang, Sumatera barat, Indonesia-25613
(2) Departemen Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Andalas, Limau Manis, Padang, Sumatera barat, Indonesia-25613
(3) Departemen Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Andalas, Limau Manis, Padang, Sumatera barat, Indonesia-25613
(4) Departemen Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Andalas, Limau Manis, Padang, Sumatera barat, Indonesia-25613
(5) Departemen Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Andalas, Limau Manis, Padang, Sumatera barat, Indonesia-25613
(*) Corresponding Author

Abstract

The continuous cell line known as T47D cells originates from the isolation of epithelial cells from the ductal breast tissue of a 54-year-old woman with metastatic breast cancer. Numerous plant species have been employed in alternative anti-breast cancer therapy, showing advancements in recent years. The aim of this systematic review is to assess the potential bioactive compounds from herbal plant extracts and analyze the effects of herbal plants on T47D breast cancer cells. This research employs a systematic approach to gather articles, encompassing related research questions, chosen databases, keyword selection, inclusion and exclusion criteria, as well as outcomes and conclusions regarding the collected articles. From the reviewed articles, several plants exhibit anti-breast cancer activity on T47D cell lines, namely Calamintha incana, Sterculia quadrifida, Psidium guajava, Uncaria nervosa, Syzygium aqueum, Capsicum annum, Bauhinia scandens, Lansium domesticum, and Garcinia cowa due to their content of bioactive compounds such as triterpenoids, alkaloids, phenolics, flavonoids, saponins, and tannins. These bioactive compounds from the plants exert significant influence on cell cycle, proliferation, fatty acid synthesis, and apoptosis of cancer cells.

Full Text:

PDF

References

Abdul, R., Wang, M. R., Zhong, C. J., Liu, Y. Y., Hou, W., & Xiong, H. R. (2022). An updated review on the antimicrobial and pharmacological properties of Uncaria (Rubiaceae). Journal of Herbal Medicine, 34, 100573.

Althaher, A. R., Oran, S. A., & Bustanji, Y. K. (2021). Chemical Composition, In vitro Evaluation of Antioxidant Properties and Cytotoxic Activity of the Essential Oil from Calamintha incana (Sm.) Helder (Lamiaceae): doi. org/10.26538/tjnpr/v5i8. 2. Tropical Journal of Natural Product Research (TJNPR), 5(8), 1333-1339.

Arnold, M., Morgan, E., Rumgay, H., Mafra, A., Singh, D., Laversanne, M., ... & Soerjomataram, I. (2022). Current and future burden of breast cancer: Global statistics for 2020 and 2040. The Breast, 66, 15-23.

DeSantis CE, Fedewa SA, Sauer AG, Kramer JL, Smith RA, Jemal A. Breast cancer statistics, 2015: convergence of incidence rates between black and white women. CA Cancer J. Clin. 2016; 66(1): 31-42.

Fadhilah, K., Wahyuono, S., & Astuti, P. (2020). A bioactive compound isolated from Duku (Lansium domesticum Corr) fruit peels exhibits cytotoxicity against T47D cell line. F1000Research, 9.

Faisal R, Shinwari L, Aziz I, Khalil AT. 2019. Therapeutic and adverse effect of commonly used medicinal plants: standardization and quality assurance. Proc Pak Acad Sci 56 (3): 1-9.

Flores, G., Wu, S. B., Negrin, A., & Kennelly, E. J. (2015). Chemical composition and antioxidant activity of seven cultivars of guava (Psidium guajava) fruits. Food chemistry, 170, 327-335.

Hassan, G. S., Georgey, H. H., George, R. F., & Mohamed, E. R. (2018). Aurones and furoaurones: Biological activities and synthesis. Bulletin of Faculty of Pharmacy, Cairo University, 56(2), 121-127.

Hefni, D., Dachriyanus, W. F., Yerizel, E., Arisanty, D., & Yusra, L. N. (2020). Cowanin, a cytotoxic xanthone from asam kandis (Garcinia cowa roxb.) reduced cell migration and induced cell cycle arrest on T47D human cancer cell. Int. J. Adv. Sci, 10, 2164-2169.

Hong LS, Ibrahim D, Kassim J. (2011). Assessment of in vivo and in vitro cytotoxic activity of hydrolysable tannin extracted from Rhizophora apiculata barks. World J Microbiol Biotechnol 27 (11): 2737-2740.

Hosseini A dan Ghorbani A. (2015). Cancer therapy with phytochemicals: evidence from clinical studies. Avicenna J Phytomed. 5 (2): 84-97.

Huang, L., Wall, M. E., Wani, M. C., Navarro, H., Santisuk, T., Reutrakul, V., & Kinghorn, A. D. (1998). New compounds with DNA strand-scission activity from the combined leaf and stem of Uvaria hamiltonii. Journal of natural products, 61(4), 446-450.

Ip, S. W., Lan, S. H., Lu, H. F., Huang, A. C., Yang, J. S., Lin, J. P., ... & Chung, J. G. (2012). Capsaicin mediates apoptosis in human nasopharyngeal carcinoma NPC-TW 039 cells through mitochondrial depolarization and endoplasmic reticulum stress. Human & experimental toxicology, 31(6), 539-549.

Ismail, T., Calcabrini, C., Diaz, A. R., Fimognari, C., Turrini, E., Catanzaro, E., ... & Sestili, P. (2016). Ellagitannins in cancer chemoprevention and therapy. Toxins, 8(5), 151.

Ito, C., Itoigawa, M., Furukawa, H., Rao, K. S., Enjo, F., Bu, P., ... & Nishino, H. (1998). Xanthones as inhibitors of Epstein–Barr virus activation. Cancer letters, 132(1-2), 113-117.

Kasuba, N. B., dan Santosa, A.., Fera, T. (2019). Karakteristik Dan Gambaran Klinis Pasien Kanker Payudara Yang Dirawat Inap Di RSUD Dr H Chasan Boesoirie Ternate Tahun 2019. Kieraha Medical Journal, 1(1)

Kemenkes RI (2022) ‘Ministry Of Health Republic Of Indonesia’, February. Availableat: https://www.kemkes.go.id/article/print/22020400002/kanker-payudara-paling-banyak-di-indonesia-kemenkes-targetkan-pemerataan-layanan-kesehatan.html.

Kim, C., & Kim, B. (2018). Anti-cancer natural products and their bioactive compounds inducing ER stress-mediated apoptosis: A review. Nutrients, 10(8), 1021.

Kristanti, A. N., Aung, E. E., Aminah, N. S., Takaya, Y., Aung, H. T., & Ramadhan, R. (2022). Bioactive triterpenoids from Indonesian medicinal plant Syzygium aqueum. Open Chemistry, 20(1), 204-211.

Kumar, S., Lathwal, E., Kumar, G., Saroha, B., Kumar, S., Mahata, S., & Nasare, V. D. (2020). Synthesis of pyrazole based novel aurone analogs and their cytotoxic activity against MCF-7 cell line. Chemical Data Collections, 30, 100559.

Kurnijasanti, R., & Fadholly, A. (2021). Cytotoxic Effect of Capsicum annum L. extract on T47D Cells: In vitro Study. Research Journal of Pharmacy and Technology, 14(6), 3389-3390.

Lianah, L., Khasanah, R. A. N., Pranatami, D. A., & Krisantini, K. (2021). Phytochemical screening and cytotoxic evaluation of Bauhinia scandens leaf extracts using HeLa and T47D cell lines. Biodiversitas Journal of Biological Diversity, 22(2).

Matsumoto, T., Kitagawa, T., Teo, S., Anai, Y., Ikeda, R., Imahori, D., ... & Watanabe, T. (2018). Structures and antimutagenic effects of onoceranoid-type triterpenoids from the leaves of Lansium domesticum. Journal of natural products, 81(10), 2187-2194.

Maulina, Sheli, Djihan, RW and Erwin. (2019). Phytochemical Screening and Root Extract Bioactivity Uncaria nervosa Elmer (bajakah). Jurnal Atomik. 4(2):100-101.

Nurhayati, A. P. D., Abdulgani, N., & Febrianto, R. (2006). Uji toksisitas ekstrak eucheuma alvarezii terhadap artemia salina sebagai studi pendahuluan potensi antikanker. Akta Kimindo, 2(1), 41-46.

Parthasarathy, A., Cross, P. J., Dobson, R. C., Adams, L. E., Savka, M. A., & Hudson, A. O. (2018). A three-ring circus: metabolism of the three proteogenic aromatic amino acids and their role in the health of plants and animals. Frontiers in molecular biosciences, 5, 29.

Plaumann, B., Fritsche, M., Rimpler, H., Brandner, G., & Hess, R. D. (1996). Flavonoids activate wild-type p53. Oncogene, 13(8), 1605-1614.

Podolak, I., Galanty, A., & Sobolewska, D. (2010). Saponins as cytotoxic agents: a review. Phytochemistry Reviews, 9, 425-474.

Prakoso, N. I., & Nita, M. T. (2023). Exploring anticancer activity of the Indonesian guava leaf (Psidium guajava L.) fraction on various human cancer cell lines in an in vitro cell-based approach. Open Chemistry, 21(1), 20230101.

Rahmawati, N., Ismail, N. H., Hamidi, D., & Wahyuni, F. S. (2023). Cytotoxic Activity Screening of Various Uncaria Spp Plants on T47d Breast Cancer Cells. Tropical Journal of Natural Product Research, 7(1).

Rollando, R., Monica, E., Afthoni, M. H., Warsito, W., Masruri, M., & Widodo, N. (2023). A Phenylpropanoid Compound from the Seeds of Sterculia quadrifida and its Cytotoxic Activity. Tropical Journal of Natural Product Research, 7(6).

Rollando, R., Warsito, W., Masruri, M., & Widodo, N. (2021). Antibacterial, Antioxidant, and Cytotoxic Flavonoid Compound from Sterculia Quadrifida Leaves: doi. org/10.26538/tjnpr/v5i11. 15. Tropical Journal of Natural Product Research (TJNPR), 5(11), 1979-1985.

Rollando, R., Yuniati, Y., & Monica, E. (2023). Bioactive Potential of Cephalosporium sp. a Fungal Endophyte Isolated from Phyllanthus niruri L. Tropical Journal of Natural Product Research, 7(4).

Sampaio, R.F., Mancini, M.C., 2007. Estudos de revisão sistemática: ´ um guia para síntese criteriosa da evidˆencia científica. Braz. J. Phys. Ther. 11 (1), 83–89.

Sarkar, A., Bhattacharjee, S., & Mandal, D. P. (2015). Induction of apoptosis by eugenol and capsaicin in human gastric cancer AGS cells-elucidating the role of p53. Asian Pacific Journal of Cancer Prevention, 16(15), 6753-6759.

Shah, M., Murad, W., Ur Rehman, N., Mubin, S., Al-Sabahi, J. N., Ahmad, M., ... & Al-Harrasi, A. (2021). GC-MS analysis and biomedical therapy of oil from n-hexane fraction of Scutellaria edelbergii Rech. f.: in vitro, in vivo, and in silico approach. Molecules, 26(24), 7676.

Sobolewska, D., Galanty, A., Grabowska, K., Makowska-Wąs, J., Wróbel-Biedrawa, D., & Podolak, I. (2020). Saponins as cytotoxic agents: an update (2010–2018). Part I—steroidal saponins. Phytochemistry reviews, 19, 139-189.

Tusanti, I., Johan, A., & Kisdjamiatun, R. A. (2014). Sitotoksisitas in vitro ekstrak etanolik buah parijoto (Medinilla speciosa, reinw. ex bl.) terhadap sel kanker payudara T47D. Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition), 2(2), 53-58.

Zhang, J. H., Lai, F. J., Chen, H., Luo, J., Zhang, R. Y., Bu, H. Q., ... & Lin, S. Z. (2013). Involvement of the phosphoinositide 3 kinase/Akt pathway in apoptosis induced by capsaicin in the human pancreatic cancer cell line PANC-1. Oncology Letters, 5(1), 43-48.

Zhang, J., Chen, D., Han, D. M., Cheng, Y. H., Dai, C., Wu, X. J., ... & Heng, X. Y. (2018). Tannic acid mediated induction of apoptosis in human glioma Hs 683

DOI: 10.23917/bioeksperimen.v10i1.23534

Article Metrics

Abstract view(s): 233 time(s)
PDF: 100 time(s)

Refbacks

  • There are currently no refbacks.