PENGARUH KOMBINASI VITAMIN ORAL B1, B6 DAN B12 TERHADAP WAKTU REAKSI PADA SUBJEK DEWASA MUDA YANG SEHAT: STUDI ACAK TERKENDALI

Imaniar Ranti(1), Ikhlas Muhammad Jenie(2)

(1) Bagian Farmakologi, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Muhammadiyah Yogyakarta
(2) Bagian Fisiologi, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Muhammadiyah Yogyakarta
(*) Corresponding Author

Abstract

ABSTRAK

Waktu reaksi adalah waktu yang diperlukan oleh mahluk hidup untuk berespon secara sengaja terhadap stimulus yang diberikan. Waktu reaksi ini mampu menunjukkan kemampuan koordinasi sistem saraf motorik dan sensorik.  Waktu reaksi akan menurun saat terjadi penurunan fungsi sistem saraf. Salah satu vitamin yang dapat menjaga fungsi saraf adalah  kombinasi vitamin oral B1, B6 dan B12. Penelitian ini bertujuan untuk mengkaji efek pemberian vitamin oral B1, B6, dan B12 terhadap waktu reaksi. Desain penelitian menggunakan uji acak terkendali double blind.  Subyek sebanyak 20 orang laki-laki dan perempuan usia 18-20 tahun, yang terbagi secara acak 10 orang sebagai kelompok intervensi dan 10 orang sebagai kelompok kontrol.  Kombinasi vitamin oral B1 100 mg, B6 200 mg dan B12 200 mcg diberikan dalam bentuk kapsul dan diminum satu kali sehari selama 14 hari.  Subyek kelompok kontrol diberi kapsul yang berisi amylum lactose sebagai plasebo.  Pada hari ke-14, dilakukan pengukuran waktu reaksi sederhana dan waktu reaksi pilihan menggunakan alat pengukur kecepatan respon.  Hasil penelitian ini menunjukkan bahwa tidak ada perbedaan bermakna waktu reaksi sederhana dan waktu reaksi pilihan antara kelompok intervensi dan kelompok kontrol.  Akan tetapi, pada sub analisis berdasarkan gender, subyek perempuan kelompok intervensi mempunyai waktu reaksi pilihan yang lebih cepat dibandingkan kontrol.

Kata Kunci: Waktu Reaksi, Kombinasi Vitamin Oral B1, B6, B12, Uji Acak Terkendali

ABSTRACT

Reaction time is the time it takes for organisme to respond the given stimulus voluntarily. This reaction time is a good indicator of sensorimotor nervous system coordination. The reaction time will decrease when there is a decrease in nervous system function. One of the vitamins that can maintain nerve function is an combination of oral vitamins B1, B6 and B12. This study aimed to examine the effect of oral vitamins B1, B6, and B12 on reaction time. The study design used a double blind randomized controlled trial. Subjects were 20 men and women aged 18-20 years, which were randomly divided 10 people as the intervention group and 10 people as the control group. The combination of oral vitamins B1 100 mg, B6 200 mg and B12 200 mcg were given in capsule form and taken once a day for 14 days. The control group subjects were given a capsule containing amylum lactose as a placebo. On day 14th, a simple and selected reaction time was measured using a response velocity measuring device. The results of this study indicate that there were no significant difference in simple and selected reaction time between the intervention group and the control group. In a further analysis stratified by gender, female subjects in the intervention group had a faster selected reaction time than controls. 

 

Keywords: Reaction Time, Oral Vitamin B1, B6, B12, Randomized Controlled Trial

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DOI: 10.23917/biomedika.v13i1.9883

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