Studi Penggunaan Obat Anti Tuberkulosis (OAT) Tahap Lanjutan pada Pasien Baru BTA Positif

Tista Ayu Fortuna(1*), Hidajah Rachmawati(2), Didik Hasmono(3), Hidayah Karuniawati(4)

(1) Universitas Muhammadiyah Surakarta
(2) Universitas Muhammadiyah Malang
(3) Universitas Airlangga
(4) Universitas Muhammadiyah Surakarta
(*) Corresponding Author

Abstract

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Tuberculosis will cause pain and death if not treated properly. OAT (Antituberculosis Drugs) is a treatment for tuberculosis patients. OAT has different dosage regimens and types of drugs. Treatment of TB patients consists of two phases (intensive and continuation phases). The continuation phase was at to kill dormant bacteria to prevent recurrence in patients. The purpose of this study was to determine and evaluate the pattern of using OAT in patients newly diagnosed rwith smear-positive at the continuation phase. This study is an observational descriptive study with results showing that the pattern of using OAT-KDT in patients was 89% and OAT-Separated was 11%. The pattern of using the OAT-KDT dose was 1x3 2KDT tablets. Another combination of antibiotics given to the patient is cotrimoxazole at a dose of 1x960mg. The side effect of OAT is an increase in serum transaminase and nausea each with a percentage of 23%. Based on the research, it can be concluded that the pattern of using OAT in Tuberculosis patients has followed the guidelines for the management of Tuberculosis treatment.

Keywords

Tuberculosis, Antituberculosis drugs, Continuation phase.

Full Text:

PDF

References

Abbas, A., 2017. Monitoring Efek Samping Obat Anti-Tuberkulosis (OAT) Pada Pengobatan Tahap Intensif Penderita TB Paru Di Kota Makassar. Journal of Agromedicine and Medical Sciences 3, 19–24.

Dinkes Klaten, 2020. Profil Kesehatan Kabupaten Klaten. Profil Kesehatan Kabupaten Klaten 21, i–iii.

Dotulong, J.F.J., Margareth, R., and Sapulete, G.D.K., 2015. Hubungan faktor risiko umur, jenis kelamin, dan kepadatan hunian dengan kejadin TB paru di desa wori. Jurnal Kedokteran Tropik, 1, pp.1–10.

Fatriyani, E dan Nunung, H., 2020. Hubungan antara Status Gizi dengan Kejadian Tuberkulosis Paru di Puskesmas : Literature Review. Borneo Student Research 2, 158–165.

Gaydos, J., McNally, A., Guo, R., William, V.R., Simonian, P.L., Burnham, E.L., 2016. Alcohol abuse and smoking alter inflammatory mediator production by pulmonary and systemic immune cells. American Journal of Physiology - Lung Cellular and Molecular Physiology 310, L507–L518.

Irawati, A., 2013. Kejadian Sindrom Obstruksi Pasca Tuberkulosis di RSU DR. Soedarso Pontianak Periode 1 Januari - 31 Desember 2010. Skripsi, Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Tanjungpura.

Karuniawati, H., Putra, O.N., Wikantyasning, E.R., 2019. Impact of pharmacist counseling and leaflet on the adherence of pulmonary tuberculosis patients in lungs hospital in Indonesia. Indian Journal of Tuberculosis, 66, pp. 364–369.

Karuniawati, H., Sudjono, T.A., Utami, H.N., Pangastuti, R.A., 2017. Risk Factors for Multidrug Resistant (MDR) in Tuberculosis Patients at Public Hospitals in Indonesia. Advanced Science Letters, 23, pp. 12469–12473.

Karuniawati, H., Wahyuni, A.S., Mirawati, H., Suryani, Sulistyarini, 2015. Pengetahuan dan Perilaku Pasien Tuberculosis terhadap Penyakit dan Pengobatannya. Prosiding Seminar Nasional dan Iinternasional, URECOL, Universitas Muhammadiyah Semarang.

Kemenkes RI, 2018. Infodatin Tuberkulosis (TB). Pusat Data dan Informasi Kementerian Kesehatan RI. ISSN 2442-7659

Kemenkes RI, 2013. Pedoman Nasional Pelayanan Kedokteran Tata Laksana Tuberkukosis. Jakarta: Kementerian Kesehatan RI.

Kemenkes RI, 2012. Pedoman Pencegahan dan Pengendalian Tuberkulosis di Fasilitas Kesehatan 35. Jakarta: Kementerian Kesehatan RI.

Kemenkes RI, 2011. Pedoman Nasional Pengendalian Tuberkulosis-Keputusan Menteri Kesehatan Republik Indonesia Nomor 364.

Kementerian Kesehatan Republik Indonesia 110. Jurnal ICT.

Kementerian Kesehatan, 2020. Pedoman Nasional Pelayanana

Kedokteran Tata Laksan Tuberkulosis - Keputusan Menteri Kesehatan Republik Indonesia. Jakarta: Kementerian Kesehatan RI.

Kementerian Kesehatan, 2016. Peraturan Menteri Kesehatan Republik Indonesia Nomor 67 tahun 2016 Tentang Penanggulangan Tuberkulosis. Jakarta: Kemenkes RI.

Lin, Y., Harries, A.D., Kumar, A.M. V, Critchley, J.A., Crevel, R. van, Owiti, P., Dlodlo, R.A., Dejgaard, A., eds., 2019. Management of Diabetes Mellitus-Tuberculosis, International Union Against Tuberculosis and Lung Disease. France: The Union.

Listiana, D., Keraman, B., Yanto, A., 2020. Pengaruh Batuk Efektif Terhadap Pengeluaran Sputum Pada Pasien TBC Di Wilayah Kerja Puskesmas Tes Kabupaten Lebong. Chmk Nursing Scientific Journal, 4, pp. 220–227.

Mulyadi dan Fitrika, Y., 2011. Hubungan Tuberkulosis Dengan Hiv/Aids. Idea Nursing Journal 2, 162–166.

Munawarah, 2018. Evaluasi Penggunaan Sediaan Fixed Dose Combination (FDC) dibandingkan dengan Tablet Lepas Obat Anti-Tuberkulosis Terhadap Resiko Terjadinya Drug Induced. Sekolah Pascasarjana Program Studi Farmasi, Universitas Hasanuddin Makassar.

Pradani, S.A dan Kundarto, W., 2018. Evaluasi Ketepatan Obat dan Dosis Obat Anti Tuberkulosis pada Pasien Anak Di Instalasi Rawat Jalan RSUDDr. Moewardi Surakarta Periode 2016-2017. JPSCR : Journal of Pharmaceutical Science and Clinical Research 3, 93.

Qiu, F., Liang, C.L., Liu, H., Zeng, Y.Q., Hou, S., Huang, S., Lai, X., Dai, Z., 2017. Impacts of cigarette smoking on immune responsiveness: Up and down or upside down?. Oncotarget, 8 (1), pp. 268–284.

Saragih, F.L dan Sirait, H., 2020. Hubungan Pengetahuan Dan Sikap Dengan Kepatuhan Minum Obat Anti Tuberkulosis Pada Pasien Tb Paru Di Puskesmas Teladan Medan Tahun 2019. Jurnal Riset Hesti Medan Akper Kesdam I/BB Medan 5, 9–15.

Wulandari, DH., 2015. Analisis Faktor-Faktor yang Berhubungan dengan Kepatuhan Pasien Tuberkulosis Paru Tahap Lanjutan Untuk Minum Obat di RS Rumah Sehat Terpadu Tahun 2015. Jurnal Administrasi Rumah Sakit 2, 17–28.

Yamazaki, M., 2017. Administration of antituberculous drugs to subjects with basic diseases. 2. Clinical studies of INH and RFP therapy on tuberculous patients with liver diseases, Kekkaku. Human Care Journal.

Article Metrics

Abstract view(s): 1158 time(s)
PDF: 15161 time(s)

Refbacks

  • There are currently no refbacks.