Reduksi Udema Kaki Mencit (Mus musculus) Terinduksi Karagenan Setelah Pemberian Ekstrak Daruju (Acanthus ilicifolius L.)

Darul Ikhwan(1), Octavian Rachmadi(2), Annisa Dyah Astari Putri(3), Ari Widiyantoro(4*)

(1) Program Studi Kimia FMIPA Universitas Tanjungpura, Pontianak, Indonesia
(2) 
(3) Program Studi Kimia FMIPA Universitas Tanjungpura, Pontianak, Indonesia
(4) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Tanjungpura University, Pontianak, Indonesia
(*) Corresponding Author

Abstract

Acanthus ilicifolius L. is one of the mangrove plants that contain a lot of potential secondary metabolites of medicinal raw materials. People of Sambas Regency of West Kalimantan Province uses leaves extract daruju to overcome the pain in the stiff and swollen. The objective of this study was to know the antiinflammatory activity of leaves extract of daruju, in the form of edema reduction of mices feet induced carrageenan. The method used in the form of maceration and partition extraction followed by phytochemical test of crude extract and the fraction of result of partition. Furthermore, the crude extract and the fraction of the result of the partition were tested for the reduction of edema mices feet induced carrageenan. The results showed that ethyl acetate fraction had the best antiinflammatory activity because it was able to decrease the edema of mices feet by 75% at 750 mg / kg BW. Ethyl acetate fraction has the ability to reduce edema because it contains group compounds of flavonoid and terpenoid.

Keywords

Achantus ilicifolius L.; Edema; Carrageenan; Antiinflamation

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References

Agoramoorthy, G., Chen F.A., Venkatesalu, V., 2008, Evaluation of antioxidant polyphenols from selected mangrove plants of India, Asian J. Chem 2, 1311-1322

Amer, M.E., Shoer, M.I.A., Kader, M.S., 2004., Alkaloids and flavone acyl glycosides from Acanthus arboreus, J. Braz. Chem. Soc. 15, 262-266

Andayani, D., Suprihartini, E., Astuti, M. 2018. Efek Antiinflmasi Ekstrak Etanol Krokot (Portulaca oleracea L.) pada Udema Tikus yang Diinduksi Karagenin, J.Pharm. Sci. Clin. Res., 1, 43-49

Andriani, D., Revianti, S., Prananingrum, W. 2020. Identification of Compounds Isolated from Methanol Extract of Acanthus ilicifolius Leaves and Evaluation of Their Antifungal and Antioxidant Activity, Biodiversitas, 21(6), 2521-2525

Anggraeny, E.N.,Pramitaningastuti, A.S., 2016. Studi Uji Daya Antiinflamasi dan Antipiretik Ekstrak Etanol Daun Lengkeng (Dimocarpus longan Lour) pada Tikus Jantan (Rattus norvegicus) Galur Wistar, Jurnal Ilmiah Farmasi, 2 (2), 44-51

Apridamayanti, P., Sanera, F., Robiyanto, R.2018. Aktivitas Antiinflamasi Ekstrak Etanol Daun Karas (Aquilaria malaccensis Lamk), Pharm.Sci.Res. 5(3), 152-158

Audina, M., Yuliet, Kaherati, K., 2018. Efektivitas Antiinflamasi Ekstrak Etanol Daun Sumambu (Hyptis capitata Jacq.) pada Tikus Jantan (Rattus norvegicus L.) yang Diinduksi Karagenan, Biocelebes, 12 (2), 17-23

Avijit, D., Sarkar, R., Howlader, S.I., Hamiduzzaman, Hossain, M.A., 2012, Phytochemical screening and evaluation of antioxidant, cytotoxic and antimicrobial properties of Acanthus ilicifolius (Acantaceae), Inter. Res. J. Pharm., 3 (8), 153-156

Chakraborty, T., Bhuniya, D., Chatterjee, M., Rahaman, M., Singha, D., 2007, Acanthus ilicifolius plant extract prevents DNA alterartions in a transplantable Ehrlich ascites carcinoma-bearing murine model, World J. Gastroenterology, 48, 6538-6548

Dewi, A.A.A.T.S., Puspawati, N.M. Suarya, P. 2015. Aktivitas Antiinflamasi Ekstrak Eter Kulit Batang Tenggulun (Protium javanicum Burm) Terhadap Edema pada Tikus Wistar yang Diinduksi dengan Karagenan, Jurnal Kimia, 9 (1), 13-19

Khotimah, S.N., Muhatdi, A., 2016. Review Artikel , Beberapa Tumbuhan yang Mengandung Senyawa Aktif Antiinflamasi, Farmaka, 14 (2), 28-40

Santi, T.D., 2015. Uji Toksisitas Akut dan Efek Antiinflamasi Ekstrak Metanol dan Ekstrak n-Heksana Daun Pepaya (Carica papaya L.), Pharm. Sci. Res., 2 (2), 101-114

Saranya, A., Ramanathan T., Selvarajan, K., Kasavanarayanan, Adam A., 2015, Traditional Medicinal uses, chemical constituents, and Biological activties of Mangrove Plant, Acanthus ilicifolius , a brief review, American-Eurasian, J. Agric. Environment., Sci., 15 (2), 243-250

Simplice, F.H., Paulin, N., Elvis, C., Acha, A.E. 2008., Protective effect of Acanthus montanus in carrageenan-induced models of local inflammation , inhibitory effect on nitric oxide (NO) production, Pharmacologyonline 2, 161-169.

DOI: 10.23917/pharmacon.v17i2.10762

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